Ziana is a gel containing a combination of clindamycin and tretinoin. Clindamycin is an antibiotic. It fights bacteria in the body.

Tretinoin is a form of vitamin A. It reduces the amount of oil released by oil glands in your skin, and helps your skin renew itself more quickly.

Ziana is used to treat severe nodular acne in adults and children who are at least 12 years old.

Ziana may also be used for purposes other than those listed in this medication guide.

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  • Veltin, Ziana
  • Applies to clindamycin / tretinoin topical: topical application gel/jelly

    As well as its needed effects, clindamycin / tretinoin topical may cause unwanted side effects that require medical attention.

    If any of the following side effects occur while taking clindamycin / tretinoin topical, check with your doctor immediately:

    More common
    Dryness and peeling of the skin
    flushing or redness of the skin
    itching
    unusually warm skin
    Less common
    Burning or stinging at the site of application
    changes in the color of the skin
    fever
    stomach cramps, tenderness, or pain
    watery or bloody diarrhea
    Some clindamycin / tretinoin topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

    Less common
    Cough
    dry skin
    headaches
    muscle aches
    pain and tenderness around the eyes and cheekbones
    shortness of breath or troubled breathing
    sore throat
    stuffy or runny nose
    tightness of the chest or wheezing
    unusual tiredness or weakness
  • Ziana (clindamycin phosphate and tretinoin) gel General dosage information for the active ingredients contained in Ziana: Clindamycin / Tretinoin Topical (topical gel) Please confirm that the medication forms on the dosage document(s) above are relevant for the specific drug you are interested in.
  • Acne

    Minocycline is a tetracycline antibiotic that fights bacteria in the body. Minocycline is used to treat many different bacterial infections, such as urinary tract infections, respiratory infections, skin infections, severe acne, gonorrhea, tick fever, chlamydia, and others. Minocycline may also be used for purposes not listed in this medication guide.