Xyrem (sodium oxybate) is a central nervous system depressant. It is used to treat cataplexy (sudden loss of muscle strength) and reduce daytime sleepiness in patients with narcolepsy.

Xyrem is also known as GHB, a known street drug of abuse. Because of the potential for abuse and the serious side effects that may occur, Xyrem is available only from a certified pharmacy under a special program called Xyrem Success Program. Your doctor must be registered in the program in order to prescribe this medicine for you.

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  • Xyrem
  • Less common
    Bloating or swelling of the face, arms, hands, lower legs, or feet
    rapid weight gain
    tingling of the hands or feet
    unusual weight gain or loss
    Incidence not known
    Anxiety
    blurred vision
    chest pain or discomfort
    decrease in the amount of urine
    dizziness
    fast or pounding heartbeat
    fever
    headache
    hives, itching, or rash
    hoarseness
    irritation
    joint pain, stiffness, or swelling
    noisy, rattling breathing
    pounding in the ears
    redness of the skin
    slow heartbeat
    sweating
    tightness in the chest
    troubled breathing at rest
    troubled breathing or swallowing
    weight gain
    If any of the following symptoms of overdose occur while taking sodium oxybate, get emergency help immediately:

    Symptoms of overdose
    Alternating periods of shallow and deep breathing
    bluish lips or skin, not breathing
    clumsiness
    coma
    confusional, agitated combative state
    consciousness, depressed
    convulsions
    drowsiness
    generalized slowing of mental and physical activity
    inability to hold bowel movement or urine
    increased sweating
    lightheadedness, dizziness, or fainting
    muscle aches or weakness
    shakiness and unsteady walk
    shivering
    sleepiness
    slow or irregular heartbeat
    trembling or other problems with muscle control or coordination
    unusual tiredness or weakness
    vomiting
    weak or feeble pulse
    Some sodium oxybate side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

    Less common
    Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
    confusion about identity, place, and time
    diarrhea
    feeling drunk
    irritability
    upper abdominal or stomach pain
    Incidence not known
    Being forgetful
    decreased appetite
    difficulty with moving
    muscle pain or stiffness
  • (sodium oxybate) oral solution