Xigduo XR contains a mix of dapagliflozin and antidiabetic drug. Dapagliflozin and antidiabetic drug square measureoral polygenic disorder medicines that facilitate management glucose levels. Dapagliflozin works by serving to the kidneys get eliminate aldohexose from your blood. antidiabetic drug lowers aldohexose production within the liver and conjointly causes your intestines to soak up less aldohexose.

Xigduo XR is employed beside diet and exercise to treat kind a pair of polygenic disorder. Dapagliflozin isn’t for treating kind one polygenic disorder.

Xigduo XR may additionally be used for functions ex-directory during this medication guide.

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  • Xigduo XR
  • Applies to dapagliflozin / metformin: oral tablet, oral tablet extended release

    As well as its needed effects, dapagliflozin / metformin may cause unwanted side effects that require medical attention.

    If any of the following side effects occur while taking dapagliflozin / metformin, check with your doctor immediately:

    More common
    Bladder pain
    bloody or cloudy urine
    change in the color, amount, or odor of vaginal discharge
    difficult, burning, or painful urination
    frequent urge to urinate
    lower back or side pain
    Rare
    Abdominal or stomach discomfort
    decreased appetite
    diarrhea
    fast, shallow breathing
    general feeling of discomfort
    large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
    muscle pain or cramping
    nausea
    shortness of breath
    sleepiness
    unusual tiredness or weakness
    Incidence not known
    Anxiety
    blurred vision
    chills
    cold sweats
    coma
    confusion
    cool, pale skin
    depression
    dizziness
    dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
    fast heartbeat
    fever
    headache
    hives, itching, or rash
    hoarseness
    increased hunger
    irritation
    joint pain, stiffness, or swelling
    nightmares
    redness of the skin
    seizures
    shakiness
    slurred speech
    sweating
    swelling of the eyelids, face, lips, hands, or feet
    tightness in the chest
    troubled swallowing
    Some dapagliflozin / metformin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

    More common
    Muscle aches
    sore throat
    stuffy or runny nose
    Less common
    Back pain
    body aches or pain
    congestion
    difficulty having a bowel movement (stool)
    tender, swollen glands in the neck
    voice changes
  • Healthcare providers should individualize the starting dose of XIGDUO XR based on the patient’s current treatment. • XIGDUO XR should be taken once daily in the morning with food with gradual dose escalation to reduce the gastrointestinal (GI) side effects due to metformin. • XIGDUO XR tablets must be swallowed whole and never crushed, cut, or chewed. Occasionally, the inactive ingredients of XIGDUO XR will be eliminated in the feces as a soft, hydrated mass that may resemble the original tablet. • Dosing may be adjusted based on effectiveness and tolerability while not exceeding the maximum recommended daily dose of 10 mg dapagliflozin and 2000 mg metformin HCl. • Patients taking an evening dose of metformin XR should skip their last dose before starting XIGDUO XR. • In patients with volume depletion, correcting this condition prior to initiation of XIGDUO XR is recommended.