What is Wellbutrin?

Wellbutrin (bupropion) is an antidepressant medication used to treat major depressive disorder and seasonal affective disorder.

Wellbutrin may also be used for purposes not listed in this medication guide.

Important information
You should not take Wellbutrin if you have seizures, an eating disorder, or if you have suddenly stopped using alcohol, seizure medication, or sedatives. If you take Wellbutrin for depression, do not also take Zyban to quit smoking.

Do not use Wellbutrin if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

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Wellbutrin may cause seizures, especially in people with certain medical conditions or when using certain drugs. Tell your doctor about all of your medical conditions and the drugs you use.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using Wellbutrin. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

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  • Wellbutrin
  • Common side effects of Wellbutrin include insomnia, nausea, weight loss, pharyngitis, dizziness, headache, constipation, and xerostomia. Other side effects include skin rash, urinary frequency, agitation, abdominal pain, migraine, arthralgia, nervousness, vomiting, anxiety, lack of concentration, tremor, palpitations, diarrhea, myalgia, tinnitus, pruritus, dysgeusia, anorexia, diaphoresis, flushing, and abnormal dreams. See below for a comprehensive list of adverse effects.

    For the Consumer
    Applies to bupropion: oral tablet, oral tablet extended release, oral tablet extended release 12 hr, oral tablet extended release 24 hr

    As well as its needed effects, bupropion (the active ingredient contained in Wellbutrin) may cause unwanted side effects that require medical attention.

    If any of the following side effects occur while taking bupropion, check with your doctor immediately:

    More common
    dry mouth
    irregular heartbeats
    shortness of breath
    trouble sleeping
    Less common
    Buzzing or ringing in the ears
    headache (severe)
    skin rash, hives, or itching
    false beliefs that cannot be changed by facts
    having extreme distrust of people
    seeing, hearing, or feeling things that are not there
    seizures (convulsions)
    trouble concentrating
    Incidence not known
    Actions that are out of control
    assaulting others
    attacking others
    being aggressive
    being impulsive
    chest pain or discomfort
    fast or pounding heartbeat
    inability to sit still
    need to keep moving
    talking, feeling, or acting with excitement
    Some bupropion side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

    More common
    Abdominal or stomach pain
    decrease in appetite
    increased sweating
    weight loss (unusual)
    Less common
    Blurred vision
    change in sense of taste
    frequent need to urinate
    sore throat
    unusual feeling of wellbeing
  • Wellbutrin dosage information:Wellbutrin (bupropion hydrochloride) tablet, film coatedWellbutrin Tablets (bupropion hydrochloride) tablet, film coatedGeneral dosage information for the active ingredient contained in Wellbutrin:Bupropion (oral tablet, extended release, oral tablet)Other Wellbutrin formulations:Wellbutrin SR (bupropion hydrochloride) tablet, film coatedWellbutrin XL (bupropion hydrochloride) tablet, extended releasePlease confirm that the medication forms on the dosage document(s) above are relevant for the specific drug you are interested in.