Estradiol is a form of estrogen, a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Estradiol transdermal skin patches are used to treat certain symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. This medicine is also used to prevent postmenopausal osteoporosis, or to treat ovarian disorders.

Estradiol transdermal may also be used for purposes not listed in this medication guide.

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  • Alora, Climara, Estraderm, Estradiol Patch, Menostar, Minivelle, Vivelle, Vivelle-Dot
  • Less common:
    Vaginal yeast infection
    Incidence not known:
    Change in vaginal discharge
    clear or bloody discharge from the nipple
    decrease in the amount of urine
    dimpling of the breast skin
    fast heartbeat
    hives, itching, or rash
    inverted nipple
    joint pain, stiffness, or swelling
    lump in the breast or under the arm
    noisy, rattling breathing
    pain or feeling of pressure in the pelvis
    pain, redness, or swelling in the arm or leg
    persistent crusting or scaling of the nipple
    redness of the skin
    redness or swelling of the breast
    sore on the skin of the breast that does not heal
    swelling of the eyelids, face, fingers, lips, hands, feet, or lower legs
    tightness in the chest
    troubled breathing at rest
    troubled breathing or swallowing
    vaginal bleeding
    If any of the following symptoms of overdose occur while taking estradiol, get emergency help immediately:

    Symptoms of overdose:
    Abdominal or stomach pain
    nausea or vomiting
    tenderness of the breasts
    unusual tiredness or weakness
  • Vivelle-Dot should be replaced twice weekly. The sites of application must be rotated, with an interval of at least 1 week allowed between applications to a particular site. The area selected should not be oily, damaged, or irritated. The waistline should be avoided, since tight clothing may rub the system off. The system should be applied immediately after opening the pouch and removing the protective liner. The system should be pressed firmly in place with the palm of the hand for about 10 seconds, making sure there is good contact, especially around the edges. In the event that a system should fall off, the same system may be reapplied. If the same system cannot be reapplied, a new system should be applied to another location. In either case, the original treatment schedule should be continued. If a woman has forgotten to apply a patch, she should apply a new patch as soon as possible. The new patch should be applied on the original treatment schedule. The interruption of treatment in women taking Vivelle-Dot might increase the likelihood of breakthrough bleeding, spotting and recurrence of symptoms.