Triprolidine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of pseudoephedrine and triprolidine is used to treat runny or stuffy nose, sneezing, itching, watery eyes, and sinus congestion caused by allergies, the common cold, or the flu.

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  • A-Phedrin, Allerfrim, Allerphed, Altafed, Aphedrid, Aprodine, Biofed-PE, Genac, Hist-PSE, Histafed, Pediatex TD, Trip-PSE, Vi-Sudo, Zymine-D
  • Stop using this medication and call your doctor at once if you have a serious side effect such as:

    fast or uneven heart rate;
    mood changes;
    tremor, seizure (convulsions);
    easy bruising or bleeding, unusual weakness;
    urinating less than usual or not at all;
    feeling short of breath; or
    dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, chest pain, uneven heartbeats, seizure).
    Less serious side effects may include:

    dizziness, drowsiness;
    dry mouth, nose, or throat;
    constipation;
    blurred vision; or
    feeling nervous or restless.
  • Usual Adult Dose for Allergic Rhinitis Tablets: Pseudoephedrine-triprolidine 60 mg-2.5 mg 1 tablet orally every 4-6 hours; do not exceed 4 doses in 24 hours. Syrup: Pseudoephedrine-triprolidine 30 mg-1.25 mg/mL oral liquid 10 mL orally every 4-6 hours; do not exceed 4 doses in 24 hours. Liquid: Pseudoephedrine-triprolidine 10 mg-0.938 mg/mL oral liquid: 2.67 mL orally every 6 hours. Do not take more than 4 doses in 24 hours. Pseudoephedrine-triprolidine 45 mg-2.5 mg/5 mL oral liquid: 5 to 10 mL orally every 4 to 6 hours. (maximum pseudoephedrine: 240 mg/24 hours).