Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Codeine is a narcotic cough suppressant. It affects the signals in the brain that trigger cough reflex.

Chlorpheniramine and codeine is a combination medicine used to treat runny nose, sneezing, itching, watery eyes, and cough caused by allergies, the common cold, or the flu.

Chlorpheniramine and codeine will not treat a cough that is caused by smoking, asthma, or emphysema.

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  • Codar AR, Codeprex, Cotab A, Endacof-C, Tuzistra XR, Zodryl AC 25, Zodryl AC Adult, Z-Tuss AC
  • Stop using chlorpheniramine and codeine and call your doctor at once if you have:

    confusion, hallucinations;
    seizure (convulsions);
    fever; or
    dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, chest pain, shortness of breath, uneven heartbeats, seizure).
    Common side effects may include:

    dizziness, drowsiness;
    sleep problems (insomnia);
    feeling restless or excited;
    stuffy nose; or
    dry mouth, nose, or throat.
  • TUZISTRA XR should be orally administered in a dose of 10 mL every 12 hours, not to exceed 2 doses (20 mL) in 24 hours.