Chlorpheniramine and pyrilamine are antihistamines that reduce the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of chlorpheniramine, phenylephrine, and pyrilamine is used to treat runny or stuffy nose, sneezing, itching, watery eyes, and sinus congestion caused by allergies, the common cold, or the flu.

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  • AllerTan, Chlorex-A 12, Conal, MyHist-PD, Nalex A 12, Phena-Plus, Phena-S, Poly Hist PD (old formulation), R-Tannate, Ru-Hist Forte, Tri-Hist Pediatric, Triotann-S Pediatric, Triple Tannate Pediatric, Triplex AD
  • Stop using this medication and call your doctor at once if you have a serious side effect such as:

    severe dizziness, anxiety, restless feeling, or nervousness;
    fast, pounding, or uneven heartbeats;
    confusion, hallucinations, unusual thoughts or behavior;
    feeling like you might pass out;
    urinating less than usual or not at all;
    easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms;
    increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure); or
    nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
    Less serious side effects may include:

    upset stomach, constipation;
    dry mouth;
    blurred vision;
    dizziness, drowsiness;
    problems with memory;
    sleep problems (insomnia); or
    feeling restless or excited (especially in children).
  • Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Cough or cold medicine is usually taken only for a short time until your symptoms clear up. Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Do not crush, chew, or break an extended-release tablet. Swallow the pill whole. Breaking or crushing the pill may cause too much of the drug to be released at one time. Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. Shake the oral suspension (liquid) well just before you measure a dose.