Short-term treatment of moderate to severe melasma (darkening) of the face. It is used in combination with sun avoidance measures, including sunscreen use. It may also be used for other conditions as determined by your doctor.

Tri-Luma is a combination topical corticosteroid, depigmentation agent, and keratolytic. Exactly how Tri-Luma works to treat melasma is unknown.

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  • Tri-Luma
  • All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

    Acne; redness, peeling, mild burning, irritation, stinging, dryness, or itching at the application site.

    Seek medical attention right away if any of these SEVERE side effects occur:
    Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); excessive hair growth; gradual blue-black darkening of the skin; inflamed hair follicles; inflammation around the mouth; loss of skin color; severe or persistent burning, redness, swelling, blistering, oozing, crusting, or irritation of the skin; symptoms of high blood sugar (eg, increased thirst, hunger, or urination; confusion; drowsiness; flushing; rapid breathing; fruit-like breath odor); thinning, softening, or discoloration of the skin.
  • Apply a thin film of TRI-LUMA Cream to the effected area once daily, at least 30 minutes before bedtime. Gently wash the face and neck with a mild cleanser. Rinse and pat the skin dry. Apply TRI-LUMA Cream to the hyperpigmented areas of melasma including about 1/2 inch of normal appearing skin surrounding each lesion. Rub lightly and uniformly into the skin. Therapy should be discontinued when control is achieved. During the day, use a sunscreen of SPF 30, and wear protective clothing. Avoid sunlight exposure. Patients may use moisturizers and/or cosmetics during the day. TRI-LUMA Cream is for topical use only. It is not for oral, ophthalmic, or intravaginal use.