Theophylline is indicated for the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, e.g., emphysema and chronic bronchitis.

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  • Theolair
  • Abdominal or stomach pain
    blurred vision
    confusion about identity, place, and time
    dark-colored urine
    decrease in frequency of urination
    decreased urine
    difficulty in passing urine (dribbling)
    dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
    dry mouth
    fast, pounding, or irregular heartbeat or pulse
    increased thirst
    irregular heartbeat
    loss of appetite
    mood changes
    muscle cramps or spasms
    muscle pain or stiffness
    nausea or vomiting
    numbness or tingling in the hands, feet, or lips
    pain or discomfort in the arms, jaw, back, or neck
    painful urination
    shakiness in the legs, arms, hands, or feet
    shortness of breath
    unusual tiredness or weakness
    vomiting of blood or material that looks like coffee grounds
  • The steady-state peak serum theophylline concentration is a function of the dose, the dosing interval, and the rate of theophylline absorption and clearance in the individual patient. Because of marked individual differences in the rate of theophylline clearance, the dose required to achieve a peak serum theophylline concentration in the 10-20 mcg/mL range varies fourfold among otherwise similar patients in the absence of factors known to alter theophylline clearance (e.g., 400-1600 mg/day in adults <60 years old and 10-36 mg/kg/day in children 1-9 years old). For a given population there is no single theophylline dose that will provide both safe and effective serum concentrations for all patients. Administration of the median theophylline dose required to achieve a therapeutic serum theophylline concentration in a given population may result in either sub-therapeutic or potentially toxic serum theophylline concentrations in individual patients. For example, at a dose of 900 mg/d in adults <60 years or 22 mg/kg/d in children 1-9 years, the steady-state peak serum theophylline concentration will be <10 mcg/mL in about 30%of patients, 10-20 mcg/mL in about 50%and 20-30 mcg/mL in about 20%of patients. The dose of theophylline must be individualized on the basis of peak serum theophylline concentration measurements in order to achieve a dose that will provide maximum potential benefit with minimal risk of adverse effects.