Sulfasalazine affects a substance in the body that causes inflammation, tissue damage, and diarrhea.

Sulfasalazine is used to treat moderate to severe ulcerative colitis.

Sulfasalazine is also used to treat rheumatoid arthritis in children and adults who have used other arthritis medicines without successful treatment of symptoms.

Sulfasalazine may also be used for purposes not listed in this medication guide.

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  • Azulfidine, Azulfidine EN-tabs, Sulfazine
  • sudden weakness or ill feeling, fever, chills, cold or flu symptoms;
    sore throat, cough, trouble breathing;
    stabbing chest pain, cough with yellow or green mucus, wheezing;
    pain when swallowing, painful mouth sores, red or swollen gums;
    rapid heart rate, rapid and shallow breathing, fainting;
    skin sores, pale skin, easy bruising, unusual bleeding; or
    jaundice (yellowing of the skin or eyes).
    Also call your doctor at once if you have:

    severe nausea or vomiting when you first start taking sulfasalazine;
    the first sign of any skin rash, no matter how mild;
    signs of a kidney problem--little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath; or
    severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
    Common side effects may include:

    nausea, vomiting, upset stomach, loss of appetite;
    headache; or
    low sperm count in men.
  • Usual Adult Dose for Rheumatoid Arthritis Delayed-release tablets: 1000 mg orally twice a day Suggested dosing regimen: Week 1: 500 mg orally once a day in the evening Week 2: 500 mg orally twice a day (morning and evening) Week 3: 500 mg orally in the morning and 1000 mg in the evening Week 4: 1000 mg orally twice a day (morning and evening)