Spironolactone is a potassium-sparing diuretic (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low.

Spironolactone is used to diagnose or treat a condition in which you have too much aldosterone in your body. Aldosterone is a hormone produced by your adrenal glands to help regulate the salt and water balance in your body.

Spironolactone also treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome. This medication is also used to treat or prevent hypokalemia (low potassium levels in the blood).

Spironolactone may also be used for purposes not listed in this medication guide.

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  • Spironolactone
  • Applies to spironolactone: oral tablet

    As well as its needed effects, spironolactone may cause unwanted side effects that require medical attention.

    If any of the following side effects occur while taking spironolactone, check with your doctor immediately:

    Incidence not known
    Abdominal or stomach cramping, burning, or tenderness
    bleeding gums
    bloody or black, tarry stools
    bloody urine
    breast pain
    chest pain
    clay-colored stools
    clear or bloody discharge from the nipple
    cloudy urine
    cough or hoarseness
    dark urine
    decrease in urine output or decrease in urine-concentrating ability
    difficulty with swallowing
    dimpling of the breast skin
    fast or irregular heartbeat
    fever with or without chills
    general feeling of tiredness or weakness
    hives, itching, or skin rash
    increased thirst
    inverted nipple
    loss of appetite
    lower back or side pain
    lump in the breast or under the arm
    muscle pain or cramps
    muscle spasms or twitching
    nausea and vomiting
    painful or difficult urination
    persistent crusting or scaling of the nipple
    pinpoint red spots on the skin
    puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
    redness or swelling of the breast
    severe stomach pain
    shakiness and unsteady walk
    sore on the skin of the breast that does not heal
    sore throat
    sores, ulcers, or white spots on the lips or in the mouth
    swelling of the face, fingers, feet, ankles, or lower legs
    swollen, painful, or tender lymph glands in the neck, armpit, or groin
    tightness in the chest
    troubled breathing
    unpleasant breath odor
    unsteadiness, trembling, or other problems with muscle control or coordination
    unusual bleeding or bruising
    unusual tiredness or weakness
    vomiting of blood or material that looks like coffee grounds
    weight gain
    yellow eyes or skin
    If any of the following symptoms of overdose occur while taking spironolactone, get emergency help immediately:

    Symptoms of overdose
    Irregular heartbeat
    numbness or tingling in the hands, feet, or lips
    rash with flat lesions or small raised lesions on the skin
    reddened skin
    weakness or heaviness of the legs
    Some spironolactone side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

    Incidence not known
    Burning feeling in the chest or stomach
    hair loss or thinning of the hair
    leg cramps
    sores, welting, or blisters
    stomach upset
    swelling of the breasts or breast soreness in both females and males
    unusual dullness or feeling of sluggishness
  • Spironolactone (oral tablet, compounding powder) Please confirm that the medication forms on the dosage document(s) above are relevant for the specific drug you are interested in.