Septra contains a combination of sulfamethoxazole and trimethoprim. Sulfamethoxazole and trimethoprim are are both antibiotics that treat different types of infection caused by bacteria.

Septra is used to treat ear infections, urinary tract infections, bronchitis, traveler’s diarrhea, shigellosis, and Pneumocystis jiroveci pneumonia.

Septra may also be used for purposes not listed in this medication guide.

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  • Bactrim, Septra, SMZ-TMP
  • Applies to sulfamethoxazole / trimethoprim: oral suspension, oral tablet

    Other dosage forms:

    intravenous solution
    As well as its needed effects, sulfamethoxazole / trimethoprim may cause unwanted side effects that require medical attention.

    If any of the following side effects occur while taking sulfamethoxazole / trimethoprim, check with your doctor immediately:

    Abdominal or stomach pain
    black, tarry stools
    blistering, peeling, or loosening of the skin
    changes in skin color
    chest pain
    cough or hoarseness
    dark urine
    fever with or without chills
    general feeling of tiredness or weakness
    joint or muscle pain
    light-colored stools
    loss of appetite
    lower back or side pain
    pain, tenderness, or swelling of the foot or leg
    painful or difficult urination
    pale skin
    red skin lesions, often with a purple center
    red, irritated eyes
    shortness of breath
    sore throat
    sores, ulcers, or white spots in the mouth or on the lips
    swollen or painful glands
    tightness in the chest
    unpleasant breath odor
    unusual bleeding or bruising
    vomiting of blood
    yellow eyes or skin
    Incidence not known
    Abdominal or stomach tenderness
    back, leg, or stomach pains
    bleeding gums
    blindness or vision changes
    blisters, hives, or itching
    blood in the urine or stools
    bluish-colored lips, fingernails, or palms
    burning, crawling, itching, numbness, painful, prickling, "pins and needles", or tingling feelings
    burning of the face or mouth
    chest pain
    cloudy urine
    continuing ringing or buzzing or other unexplained noise in the ears
    cracks in the skin
    decreased frequency or amount of urine
    diarrhea, watery and severe, which may also be bloody
    difficulty with breathing
    difficulty with swallowing
    fainting spells
    general body swelling
    general feeling of discomfort or illness
    hair loss
    hearing loss
    increased thirst
    irregular heartbeat
    large, flat, blue, or purplish patches in the skin
    large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
    loss of heat from the body
    muscle or joint pain
    not able to pass urine
    numbness or tingling in the hands, feet, or lips
    pain or burning while urinating
    pinpoint red spots on the skin
    puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
    raised red swellings on the skin, the buttocks, legs, or ankles
    redness of the white part of the eyes
    redness, swelling, or soreness of the tongue
    sores, ulcers, or white spots on the lips or in the mouth
    soreness of the muscles
    stiff neck or back
    swelling of the face, hands, legs, and feet
    unsteadiness, trembling, or other problems with muscle control or coordination
    unusual weight loss
    weakness in the hands or feet
    weakness or heaviness of the legs
    weight gain
    Some sulfamethoxazole / trimethoprim side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

    More common
    Passing of gas
    Incidence not known
    feeling of constant movement of self or surroundings
    feeling sad or empty
    increased sensitivity of the skin to sunlight
    lack of feeling or emotion
    loss of interest or pleasure
    redness or other discoloration of the skin
    seeing, hearing, or feeling things that are not there
    sensation of spinning
    severe sunburn
    trouble concentrating
    trouble sleeping
    weight loss
  • Septra (trimethoprim and sulfamethoxazole) tablet General dosage information for the active ingredients contained in Septra: Sulfamethoxazole / Trimethoprim (oral tablet, oral suspension, intravenous solution) Please confirm that the medication forms on the dosage document(s) above are relevant for the specific drug you are interested in.
  • Urinary Tract Infection

    Doxycycline is a tetracycline antibiotic. It fights bacteria in the body. Doxycycline is used to treat many different bacterial infections, such as acne, urinary tract infections, intestinal infections, eye infections, gonorrhea, chlamydia, periodontitis (gum disease), and others. Doxycycline is also used to treat blemishes, bumps, and acne-like lesions caused by rosacea. It will not treat facial redness caused by rosacea. Some forms of doxycycline are used to prevent malaria, to treat anthrax, or to treat infections caused by mites, ticks, or lice.