SAMe is used by mouth for depression, anxiety, heart disease, fibromyalgia, abdominal pain, osteoarthritis, bursitis, tendonitis, chronic lower back pain, dementia, Alzheimer’s disease, slowing the aging process, chronic fatigue syndrome (CFS), improving mental performance, liver disease, and Parkinson’s disease. It is also used for attention deficit-hyperactivity disorder (ADHD), multiple sclerosis, spinal cord injury, seizures, migraine headache, lead poisoning, to break down a chemical in the body called bilirubin, or to help with disorders related to the buildup of a chemical called porphyrin or its precursors.

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  • SAMe
  • Pregnancy: SAMe is POSSIBLY SAFE when given intravenously (by IV) in the short-term during the third trimester of pregnancy. An 800 mg dose of SAMe has been used intravenously for 14-20 days without any adverse effects. There is not enough reliable information about the safety of taking higher doses of SAMe for longer periods of time or during the earlier trimesters of pregnancy. Stay on the safe side and avoid use.

    Breast-feeding: There is not enough reliable information about the safety of taking SAMe if you are pregnant or breast feeding. Stay on the safe side and avoid use.

    Children: SAMe is POSSIBLY SAFE when taken by mouth or used intravenously (by IV) in children in the short-term.

    Bipolar disorder: Use of SAMe can cause people with bipolar disorder to convert from depression to mania.

    Inherited disorder called Lesch-Nyhan syndrome: SAMe might make symptoms of Lesch-Nyhan syndrome worse.

    Parkinson's disease: SAMe might make Parkinson's symptoms worse.

    Surgery: SAMe might affect the central nervous system. This could interfere with surgery. Stop taking SAMe at least 2 weeks before a scheduled surgery.
  • BY MOUTH: For depression: Up to 1600 mg of SAMe daily in two divided doses for up to 8 weeks has been used alone or together with antidepressant medications. A combination product (DDM Metile, Omeopiacenza, Piacenza, Italy) containing 250 mg of SAMe taken twice daily for 12 months has been used. For osteoarthritis: 600-1200 mg of SAMe daily in up to three divided doses for up to 84 days has been used. For cirrhosis: 600 mg of SAMe daily for one month has been used. A combination 30 mg of SAMe plus 100 mcg of vitamin B12 six times daily for 30 days has been used. For fibromyalgia: 800 mg per of SAMe daily in two divided doses for 6 weeks has been used. For conditions in which bile flow from the liver is slow or blocked (Intrahepatic cholestasis): 500 mg of SAMe taken twice daily until delivery or 1600 mg taken daily in two divided doses for 2 weeks has been used. For sexual dysfunction: 400 mg of SAMe taken twice daily for 2 weeks, then increased to 800 mg twice daily for another 6 weeks, has been used. BY INJECTION: For depression: 400-800 mg of SAMe has been used intravenously (by IV) for 2-4 weeks. 45-400 mg of SAMe has been injected as a shot daily for 1-4 weeks, with or without antidepressant drugs. 200 mg of SAMe has been injected as a shot daily along with 400 mg taken by mouth in two divided doses for 6 weeks. For osteoarthritis: 400 mg of SAMe has been given by IV daily for 5 days, followed by 600 mg of SAMe taken by mouth in three divided doses for 23 days. 60 mg of SAMe injected as a shot for 7 days has also been used. For cirrhosis: 800 mg of SAMe has been used by IV once daily for 2 weeks, or 250 mg twice daily for 30 days. 1000 mg of a specific product (Transmetil, Abbott SPA) given by IV has been used daily for 7 days. 100 mg of SAMe given as a shot once daily for 30 days has also been used. For fibromyalgia: 400 mg of SAMe given by IV daily for 15 days has been used. 200 mg of SAMe given as a shot daily for 21 days has also been used.