Short-term treatment of pain.

Reprexain is an opioid analgesic and nonsteroidal anti-inflammatory drug (NSAID) combination. Exactly how it works is not known. Ibuprofen may block certain substances in the body that cause inflammation. Hydrocodone may affect opiate receptors in the brain to decrease pain.

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  • Examples include Reprexain and Vicoprofen
  • Anxiety; constipation; diarrhea; dizziness; drowsiness; dry mouth; gas; headache; heartburn; increased sweating; nausea; nervousness; stomach pain; trouble sleeping; vomiting; weakness.

    Seek medical attention right away if any of these SEVERE side effects occur:
    Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue); bloody, black, or tarry stools; blurred vision or other eye or vision problems; chest pain; confusion; fainting; numbness of an arm or leg; one-sided weakness; severe or persistent headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; slow or shallow breathing; sudden or unexplained weight gain; swelling of hands, legs, or feet; symptoms of kidney problems (eg, not able to pass urine, change in how much urine is passed, blood in the urine, a big weight gain); symptoms of liver problems (eg, dark urine, pale stools, persistent loss of appetite, right-sided stomach pain, unusual nausea or tiredness, yellowing of the skin or eyes); unusual bruising or bleeding; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds.
  • Carefully consider the potential benefits and risks of REPREXAIN™ and other treatment options before deciding to use REPREXAIN™. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS). After observing the response to initial therapy with REPREXAIN™, the dose and frequency should be adjusted to suit an individual patient's needs. For the short-term (generally less than 10 days) management of acute pain, the recommended dose of REPREXAIN™ is one tablet every 4 to 6 hours, as necessary. Dosage should not exceed 5 tablets in a 24-hour period. It should be kept in mind that tolerance to hydrocodone can develop with continued use and that the incidence of untoward effects is dose related.