Treating severe rheumatoid arthritis (RA) in certain adults. It is also used to treat polyarticular juvenile idiopathic arthritis in certain children. It is also used to control the symptoms of psoriasis in adults. It may be used alone or with other medicines. It may also be used for other conditions as determined by your doctor.

Rasuvo is an antimetabolite. It works to treat psoriasis by slowing the growth of abnormal skin cells. Exactly how Rasuvo works to treat rheumatoid arthritis is unknown. It reduces symptoms of inflammation (eg, swelling, pain, stiffness) caused by rheumatoid arthritis.

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  • Examples include Otrexup and Rasuvo
  • Diarrhea; dizziness; general body discomfort; headache; indigestion; loss of appetite; mild hair loss; mild sore throat; mild stomach pain; nausea; stuffy or runny nose; tiredness; vomiting.

    Seek medical attention right away if any of these SEVERE side effects occur:
    Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); back pain; black or bloody stools; blood in the urine; bone pain; calf or leg pain, redness, swelling, or tenderness; change in amount of urine produced; chest pain; confusion; coughing up blood; decreased coordination; difficult or painful urination; dry cough; enlargement of the breasts (in males); fainting; fever, chills, or persistent sore throat; inability to move; irritability; menstrual changes; mental or mood changes; mouth or tongue sores or swelling; muscle weakness; neck stiffness; night sweats; one-sided weakness; red, swollen, blistered, or peeling skin; red or irritated eyes; seizures; severe or persistent diarrhea or vomiting; severe or persistent headache, drowsiness, dizziness, or light-headedness; shortness of breath; sores in your mouth, throat, nose, or eyes; speech changes; swollen glands; symptoms of liver problems (eg, dark urine, pale stools, persistent loss of appetite, severe stomach pain, yellowing of the skin or eyes); symptoms of pancreas inflammation (eg, severe stomach pain with or without nausea or vomiting); unexplained weight loss; unusual bleeding or bruising; unusual pain and discoloration of the skin; unusual tiredness or weakness; vaginal discharge; vision loss or other vision changes (eg, blurred vision); vomit that looks like coffee grounds.
  • Rheumatoid Arthritis including Polyarticular Juvenile Idiopathic Arthritis Recommended starting dose of methotrexate: Adult RA: 7.5 mg as a single oral or subcutaneous dose once weekly. pJIA: 10 mg/m2 once weekly. For patients switching from oral methotrexate to Rasuvo, consider any differences in bioavailability between oral and subcutaneously administered methotrexate. Dosages may be adjusted gradually to achieve an optimal response. Limited experience shows a significant increase in the incidence and severity of serious toxic reactions, especially bone marrow suppression, at doses greater than 20 mg/wk in adults. Although there is experience with doses up to 30 mg/m2/wk in children, there are too few published data to assess how doses over 20 mg/m2/wk might affect the risk of serious toxicity in children. Experience does suggest, however, that children receiving 20 to 30 mg/m2/wk (0.65 to 1.0 mg/kg/wk) may have better absorption and fewer gastrointestinal side effects if methotrexate is administered either intramuscularly or subcutaneously.