Promethazine is in a group of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It works by changing the actions of chemicals in your brain. Promethazine also acts as an antihistamine. It blocks the effects of the naturally occurring chemical histamine in your body.

Promethazine is used to treat allergy symptoms such as itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes. It also prevents motion sickness, and treats nausea and vomiting or pain after surgery. It is also used as a sedative or sleep aid.

Promethazine is not for use in treating symptoms of asthma, pneumonia, or other lower respiratory tract infections.

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  • Phenergan
  • Convulsions (seizures)
    difficult or unusually fast breathing
    fast heartbeat or irregular pulse
    high fever
    high or low (irregular) blood pressure
    increased sweating
    loss of bladder control
    severe muscle stiffness
    unusually pale skin
    unusual tiredness or weakness
    If any of the following side effects occur while taking promethazine, check with your doctor immediately:

    Incidence not known
    Abdominal or stomach pain
    black, tarry stools
    bleeding gums
    blood in urine or stools
    bloody nose
    blurred vision
    chest pain or discomfort
    chills
    clay-colored stools
    confusion as to time, place, or person
    cough or hoarseness
    dark urine
    decreased awareness or responsiveness
    difficulty or troubled breathing
    double vision
    fast, pounding, or irregular heartbeat or pulse
    fever with or without chills
    fixed position of eye
    headache
    heavier menstrual periods
    high fever
    holding false beliefs that cannot be changed by fact
    hyperexcitability
    increased or decreased blood pressure
    increased sweating
    irregular, fast or slow, or shallow breathing
    itching
    large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
    lightheadedness, dizziness, or fainting
    loss of appetite
    loss of bladder control
    lower back or side pain
    mimicry of speech or movements
    mutism
    nasal stuffiness
    nausea
    negativism
    nightmares
    noisy breathing
    not breathing
    painful or difficult urination
    pale or blue lips, fingernails, or skin
    peculiar postures or movements, mannerisms or grimacing
    pinpoint red spots on skin
    seeing double
    seeing, hearing, or feeling things that are not there
    seizures
    severe muscle stiffness
    severe sleepiness
    shortness of breath
    skin rash
    slow or irregular heartbeat
    sore throat
    sores, ulcers, or white spots on lips or in mouth
    sticking out of tongue
    swollen glands
    tightness in chest
    tremors
    uncontrolled twisting movements of neck
    unpleasant breath odor
    unusual bleeding or bruising
    unusual excitement, nervousness, or restlessness
    unusual tiredness or weakness
    vomiting of blood
    wheezing
    yellow eyes or skin
    Symptoms of overdose
    Discouragement
    dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
    dry mouth
    excessive muscle tone
    feeling of warmth
    feeling sad or empty
    irritability
    lack of appetite
    loss of interest or pleasure
    muscle tension or tightness
    overactive reflexes
    pupils of eyes large and not moving or responding to light
    redness of the face, neck, arms and occasionally, upper chest
    shakiness and unsteady walk
    sudden death
    trouble concentrating
    trouble sleeping
    unconsciousness
    unsteadiness, trembling, or other problems with muscle control or coordination
    unusual paleness
    Some promethazine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

    Incidence not known
    blistering, crusting, irritation, itching, or reddening of skin
    continuing ringing or buzzing or other unexplained noise in ears
    cracked, dry, scaly skin
    dizziness
    drowsiness
    excitation
    false or unusual sense of well-being
    hearing loss
    hives or welts
    increased sensitivity of skin to sunlight
    lack of coordination
    loss of strength or energy
    muscle pain or weakness
    redness or other discoloration of skin
    relaxed and calm
    sunburn
    swelling
    unable to sleep
    vomiting
  • (rectal suppository, oral tablet, oral syrup, injectable solution, compounding powder)