Prograf (tacrolimus) lowers your body’s immune system. The immune system helps your body fight infections. The immune system can also fight or “reject” a transplanted organ such as a liver or kidney. This is because the immune system treats the new organ as an invader.

Prograf is used together with other medicines to prevent your body from rejecting a heart, liver, or kidney transplant.

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  • Astagraf XL, Envarsus XR, Hecoria, Prograf
  • More common
    Abdominal or stomach pain
    abnormal dreams
    agitation
    chills
    confusion
    convulsions (seizures)
    diarrhea
    dizziness
    fever and sore throat
    flu-like symptoms
    frequent urination
    headache
    itching
    loss of appetite
    loss of energy or weakness
    mental depression
    muscle trembling or twitching
    nausea
    pale skin
    seeing or hearing things that are not there
    shortness of breath
    skin rash
    swelling of the feet or lower legs
    tingling
    trembling and shaking of the hands
    trouble sleeping
    unusual bleeding or bruising
    unusual tiredness or weakness
    vomiting
    Less common
    Blurred vision
    chest pain
    increased sensitivity to pain
    muscle cramps
    numbness or pain in the legs
    ringing in the ears
    sweating
    Rare
    Enlarged heart
    flushing of the face or neck
    general feeling of discomfort or illness
    weight loss
    Incidence not known
    Black, tarry stools
    blistering, peeling, loosening of the skin
    bloating
    bloody urine
    constipation
    cough
    drowsiness
    fainting
    fast, slow, or irregular heartbeat
    heartburn
    increased thirst
    indigestion
    joint or muscle pain
    lightheadedness
    lower back or side pain
    pinpoint red spots on the skin
    pounding or rapid pulse
    red skin lesions, often with a purple center
    red, irritated eyes
    skin sores
    ulcers or white spots in the mouth or on the lips
    weakness
    weight gain
    yellow eyes or skin
    Some tacrolimus side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

    More common
    Acid or sour stomach
    belching
    difficulty with moving
    lack or loss of strength
    muscle pain or stiffness
    Less common
    Body aches or pain
    burning or stinging of the skin
    cracks in the skin
    crying
    delusions
    dementia
    depersonalization
    dysphoria
    euphoria
    excessive muscle tone
    feeling of constant movement of self or surroundings
    feeling that others are watching you or controlling your behavior
    feeling that others can hear your thoughts
    increased sensitivity of the skin to sunlight
    large, flat, blue or purplish patches in the skin
    loss of strength or energy
    muscle tension or tightness
    painful blisters on the trunk of the body
    painful cold sores or blisters on the lips, nose, eyes, or genitals
    paranoia
    quick to react or overreact emotionally
    rapidly changing moods
    redness or other discoloration of the skin
    restlessness
    scaly skin
    sensation of spinning
    severe mood or mental changes
    severe sunburn
    sleepiness or unusual drowsiness
    sore mouth or tongue
    sores on the skin
    swelling or inflammation of the mouth
    tender, swollen glands in the neck
    unusual behavior
    white patches in the mouth, tongue, or throat
    Incidence not known
    Change in color vision
    decreased weight
    difficulty seeing at night
    feeling hot and cold
    hearing loss
    sudden sweating
  • (tacrolimus) capsule, gelatin coated; injection, solution