Progesterone is a female hormone important for the regulation of ovulation and menstruation.

Progesterone is used to cause menstrual periods in women who have not yet reached menopause but are not having periods due to a lack of progesterone in the body. It is also used to prevent overgrowth in the lining of the uterus in postmenopausal women who are receiving estrogen hormone replacement therapy.

Progesterone should not be used to prevent heart disease or dementia, because this medicine may actually increase your risk of developing these conditions.

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  • First Progesterone MC10, Menopause Formula Progesterone, Prometrium
  • More common:
    Chest pain
    cold or flu-like symptoms
    cough or hoarseness
    problems with urination
    Less common:
    Clear or bloody discharge from the nipple
    dimpling of the breast skin
    inverted nipple
    lump in the breast or under the arm
    persistent crusting or scaling of the nipple
    redness or swelling of the breast
    sore on the skin of the breast that does not heal
    Incidence not known:
    Abdominal or stomach pain
    blurred vision
    change in vaginal discharge
    clay-colored stools
    cleft lip or palate
    darkened urine
    difficult or labored breathing
    difficulty with swallowing
    difficulty with walking
    dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
    fast, pounding, or irregular heartbeat or pulse
    irregular heartbeat
    joint pain, stiffness, or swelling
    loss of appetite
    noisy breathing
    numbness or tingling in the face, arms, or legs
    pain or feeling of pressure in the pelvis
    pains in the stomach, side, or abdomen, possibly radiating to the back
    pounding in the ears
    puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
    redness of the skin
    shortness of breath
    slow heartbeat
    spontaneous abortion
    stomach or pelvic discomfort, aching, or heaviness
    swelling of the eyelids, face, lips, hands, or feet
    tightness in the chest
    trouble speaking, thinking, or walking
    unpleasant breath odor
    unusual tiredness or weakness
    vaginal bleeding
    vomiting of blood
    yellow eyes or skin
  • Usual Adult Dose for Amenorrhea 5 to 10 mg IM for six to eight consecutive days. 400 mg orally for 10 days. Give dose in the evening. Secondary Amenorrhea: 90 mg intravaginally, 4% gel, every other day for a total of six doses. If no response observed, the administration of the 8% gel every other day for a total of six doses may be used. Usual Adult Dose for Uterine Bleeding 5 to 10 mg IM daily for 6 doses. Usual Adult Dose for Endometrial Hyperplasia - Prophylaxis 200 mg orally for 12 consecutive days, per 28 day cycle. Give dose in the evening. Usual Adult Dose for Progesterone Insufficiency Assisted Reproductive Technology (ART) - Gel: 90 mg of the 8% gel, once daily intravaginally, in women who require supplementation. 90 mg of the 8% gel, twice daily intravaginally, in women with partial or complete ovarian failure who require replacement. If pregnancy occurs, therapy with the intravaginal gel may be continued until placental autonomy is achieved, up to 10 to 12 weeks. Assisted Reproductive Technology (ART) - Vaginal Insert 100 mg administered vaginally two or three times daily starting at oocyte retrieval and continuing for up to 10 weeks total duration. Efficacy in women 35 years of age and older has not been clearly established. The appropriate dose in this age group has not been determined. Progesterone deficiency associated with menopause and perimenopause: progesterone 1.7% topical cream: rub 1/4 to 1/2 teaspoon into the palms of the hands, soles of the feet, or other soft areas of skin once or twice daily. Usual Adult Dose for Premature Labor Study (n=459) - National Institute of Child Health and Human Development (NICHD) - Prevention of Recurrent Preterm Delivery in Women at High Risk: 17-alpha-hydroxyprogesterone caproate (17P) 250 mg IM once weekly starting on the 21st week of gestation through time of delivery or week 36 of gestation. Study (n=142) - Reduce Incidence of Spontaneous Preterm Birth in Women at Increased Risk: 100 mg vaginal suppository daily, between 24 and 34 weeks of gestation. Usual Adult Dose for Seizures (Study=25) - Catamenial epilepsy [complex partial or secondary generalized motor seizures]: 200 mg lozenge three times daily administered in relation to pattern of seizure exacerbation during luteal phase of menstrual cycle. For patients with perimenstrual exacerbation, dose was provided on day 23 through day 25 of menstrual cycle. For patients with seizure exacerbation during entire luteal phase, dose was provided on day 15 through day 25 of each menstrual cycle. The desired progesterone serum level was between 5 and 25 ng/mL 4 hours after taking the lozenge. All patients continued taking their best antiseizure medication.