Progesterone is a female hormone important for ovulation and menstruation. Progesterone causes changes in the lining of your uterus, making it easier for a fertilized egg to attach to the uterus at the beginning of pregnancy. Progesterone then helps your body maintain the pregnancy.

Progesterone vaginal (for use in the vagina) is used to cause menstrual periods in women who have not yet reached menopause but are not having periods due to a lack of progesterone in the body.

Progesterone vaginal is also used in fertility treatment as part of Assisted Reproductive Technology (ART) for women unable to get pregnant due to a lack of natural progesterone in the body.

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  • Crinone, Endometrin, FIRST-Progesterone VGS 200, Prochieve
  • More common
    Chest pain
    chills
    cold or flu-like symptoms
    cough or hoarseness
    fever
    problems with urination
    Less common
    Clear or bloody discharge from the nipple
    dimpling of the breast skin
    inverted nipple
    lump in the breast or under the arm
    persistent crusting or scaling of the nipple
    redness or swelling of the breast
    sore on the skin of the breast that does not heal
    Incidence not known
    Abdominal or stomach pain
    bloating
    blurred vision
    change in vaginal discharge
    clay-colored stools
    cleft lip or palate
    confusion
    constipation
    darkened urine
    diarrhea
    difficult or labored breathing
    difficulty with swallowing
    difficulty with walking
    dizziness
    dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
    fainting
    fast, pounding, or irregular heartbeat or pulse
    headache
    hives
    indigestion
    irregular heartbeat
    irritation
    itching
    joint pain, stiffness, or swelling
    lightheadedness
    loss of appetite
    nausea
    nervousness
    noisy breathing
    numbness or tingling in the face, arms, or legs
    pain or feeling of pressure in the pelvis
    pains in the stomach, side, or abdomen, possibly radiating to the back
    pounding in the ears
    puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
    rash
    redness of the skin
    shortness of breath
    slow heartbeat
    spontaneous abortion
    stomach or pelvic discomfort, aching, or heaviness
    sweating
    swelling of the eyelids, face, lips, hands, or feet
    tightness in the chest
    trouble speaking, thinking, or walking
    unpleasant breath odor
    unusual tiredness or weakness
    vaginal bleeding
    vomiting
    vomiting of blood
    wheezing
    yellow eyes or skin
    Some progesterone side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

    More common
    Breast pain or tenderness
    depression
    muscle or joint pain
    white or brownish vaginal discharge
    worry
    Incidence not known
    Attack, assault, or force
    blurred or loss of vision
    change in walking and balance
    changes in behavior
    changes in patterns and rhythms of speech
    choking
    clumsiness or unsteadiness
    confusion about identity, place, and time
    continuing ringing or buzzing or other unexplained noise in the ears
    decreased awareness or responsiveness
    difficulty with moving
    disturbed color perception
    double vision
    drowsiness
    extreme dizziness or drowsiness
    feeling drunk
    feeling of constant movement of self or surroundings
    feeling of unreality
    hair loss or thinning of the hair
    halos around lights
    hearing loss
    hives or welts
    longer or heavier menstrual periods
    loss of consciousness
    muscle cramps
    muscle stiffness
    night blindness
    normal menstrual bleeding occurring earlier, possibly lasting longer than expected
    overbright appearance of lights
    redness of the skin
    relaxed and calm
    sensation of spinning
    sense of detachment from self or body
    severe sleepiness
    sleepiness
    slurred speech
    swollen tongue
    thoughts of killing oneself
    tunnel vision
    weight changes
  • (progesterone) gel