Procarbazine is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Procarbazine is given with other cancer medicines to treat Hodgkin’s Disease (a type of blood cancer).

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  • Matulane
  • Rare
    Chest pain (severe)
    enlarged pupils of eyes
    fast or slow heartbeat
    headache (severe)
    increased sensitivity of eyes to light
    increased sweating (possibly with fever or cold, clammy skin)
    stiff or sore neck
    If any of the following side effects occur while taking procarbazine, check with your doctor immediately:

    Less common
    Black, tarry stools
    blood in urine or stools
    bloody vomit
    cough or hoarseness
    fever or chills
    lower back or side pain
    painful or difficult urination
    pinpoint red spots on skin
    unusual bleeding or bruising
    If any of the following side effects occur while taking procarbazine, check with your doctor or nurse as soon as possible:

    More common
    Confusion
    convulsions (seizures)
    cough
    hallucinations (seeing, hearing, or feeling things that are not there)
    missing menstrual periods
    shortness of breath
    thickening of bronchial secretions
    tiredness or weakness (continuing)
    Less common
    Diarrhea
    sores in mouth and on lips
    tingling or numbness of fingers or toes
    unsteadiness or awkwardness
    yellow eyes or skin
    Rare
    Fainting
    skin rash, hives, or itching
    wheezing
    Some procarbazine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

    More common
    Drowsiness
    muscle or joint pain
    muscle twitching
    nausea and vomiting
    nervousness
    nightmares
    trouble in sleeping
    unusual tiredness or weakness
    Less common
    Constipation
    darkening of skin
    difficulty in swallowing
    dizziness or lightheadedness when getting up from a lying or sitting position
    dry mouth
    feeling of warmth and redness in face
    headache
    loss of appetite
    mental depression
  • (oral capsule)