Probenecid helps your body pass uric acid out through the urine, which lowers the levels of uric acid in the body.

Probenecid is used to treat gout and gouty arthritis. Probenecid is also sometimes given together with penicillin antibiotics to make them more effective.

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  • Benemid
  • Rare
    Fast or irregular breathing
    puffiness or swellings of the eyelids or around the eyes
    shortness of breath, troubled breathing, tightness in chest, or wheezing
    changes in the skin color of the face occurring together with any of the other side effects listed here
    or skin rash, hives, or itching occurring together with any of the other side effects listed here
    If any of the following side effects occur while taking probenecid, check with your doctor or nurse as soon as possible:

    Less common
    Bloody urine
    difficult or painful urination
    lower back or side pain (especially if severe or sharp)
    skin rash, hives, or itching (occurring without other signs of an allergic reaction)
    Rare
    Cloudy urine
    cough or hoarseness
    fast or irregular breathing
    fever
    pain in back and/or ribs
    sores, ulcers, or white spots on lips or in mouth
    sore throat and fever with or without chills
    sudden decrease in the amount of urine
    swelling of face, fingers, feet, and/or lower legs
    swollen and/or painful glands
    unusual bleeding or bruising
    unusual tiredness or weakness
    yellow eyes or skin
    weight gain
    Some probenecid side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

    More common
    Headache
    joint pain, redness, or swelling
    loss of appetite
    nausea or vomiting (mild)
    Less common
    Dizziness
    flushing or redness of face (occurring without any signs of an allergic reaction)
    frequent urge to urinate
    sore gums
  • (oral tablet)