Prilosec (omeprazole) is a proton pump inhibitor that decreases the amount of acid produced in the stomach.

Prilosec is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions caused by excess stomach acid. Omeprazole is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid).

Prilosec may also be given together with antibiotics to treat gastric ulcer caused by infection with helicobacter pylori (H. pylori).

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  • FIRST Omeprazole, PriLOSEC, PriLOSEC OTC, Zegerid (Original Formulation)
  • Rare
    Back, leg, or stomach pain
    bleeding or crusting sores on the lips
    blisters
    bloody or cloudy urine
    chills
    continuing ulcers or sores in the mouth
    difficult, burning, or painful urination
    fever
    frequent urge to urinate
    general feeling of discomfort or illness
    joint pain
    loss of appetite
    muscle aches or cramps
    pain
    red or irritated eyes
    redness, tenderness, itching, burning, or peeling of the skin
    skin rash or itching
    sore throat
    sores, ulcers, or white spots on the lips, in the mouth, or on the genitals
    unusual bleeding or bruising
    unusual tiredness or weakness
    Incidence not known
    Drowsiness
    fast, racing, or uneven heartbeat
    mood or mental changes
    muscle spasms (tetany) or twitching seizures
    nausea or vomiting
    trembling
    If any of the following symptoms of overdose occur while taking omeprazole, get emergency help immediately:

    Symptoms of overdose
    Blurred vision
    confusion
    dryness of the mouth
    flushing
    headache
    increased sweating
    Some omeprazole side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

    Less common
    Body aches or pain
    chest pain
    constipation
    cough
    diarrhea or loose stools
    difficulty with breathing
    dizziness
    ear congestion
    gas
    heartburn
    loss of voice
    muscle pain
    nasal congestion
    runny nose
    sneezing
    unusual drowsiness
  • (omeprazole magnesium) capsule, delayed release; granule, delayed release