Treating menopausal symptoms (eg, hot flashes, vaginal dryness). It is used to prevent osteoporosis (weak bones) after menopause in certain patients. It may also be used for other conditions as determined by your doctor.

Premphase is a combination of estrogen and progestin hormones. It works by replacing these hormones in the body when the body does not make enough on its own.

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  • Examples include Premphase and Prempro
  • Breast tenderness or pain; hair loss; headache; mild fluid retention; mild nausea or vomiting; spotting or breakthrough bleeding; stomach cramps or bloating.

    Seek medical attention right away if any of these SEVERE side effects occur:
    Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); abnormal vaginal bleeding; breast lumps or pain; bulging eyes; calf or leg pain, swelling, redness, or tenderness; chest pain; coughing up blood; fainting; mental or mood changes (eg, depression); migraine headache; new or worsening memory problems; severe or persistent dizziness or headache; severe or persistent stomach pain or tenderness; shortness of breath; swelling of hands or feet; symptoms of heart attack (eg, chest, jaw, or arm pain; fainting; sudden, severe nausea or vomiting; unusual sweating; weakness); symptoms of liver problems (eg, dark urine, pale stools, yellowing of the skin or eyes); symptoms of stroke (eg, one-sided weakness, slurred speech, confusion); unusual vaginal discharge, itching, or odor; unusual weakness or fatigue; vision loss or other vision changes; vomiting.
  • Regimen 1 (Cyclic Combined Estrogen-Progestin Therapy): Conjugated estrogens 0.625 mg orally once a day AND Medroxyprogesterone acetate 5 mg orally once a day for 14 days per month. -or- Regimen 2 (Continuous Combined Estrogen-Progestin Therapy): Conjugated estrogens 0.3 mg orally once a day AND Medroxyprogesterone acetate 1.5 mg orally once a day or conjugated estrogens 0.625 mg orally once a day AND Medroxyprogesterone acetate 2.5 mg or 5 mg orally once a day. Long-term therapy (for more than 5 years) is generally necessary in order to obtain substantive benefits in reducing the risk of bone fracture. Maximal benefits are obtained if estrogen therapy is initiated as soon after menopause as possible. The optimal duration of therapy has not been definitively determined.