PrecedexTM is indicated for sedation of initially intubated and mechanically ventilated patients during treatment in an intensive care setting. Precedex should be administered by continuous infusion not to exceed 24 hours.
Precedex has been continuously infused in mechanically ventilated patients prior to extubation, during extubation, and post-extubation. It is not necessary to discontinue Precedex prior to extubation.
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Hypotension, bradycardia, dry mouth; transient hypertension (w. loading dose), sinus arrest.
Adult: Individualize. Give by continuous infusion not to exceed 24hrs. Initiation of ICU sedation: give loading infusion of 1mcg/kg over 10 minutes; >65yrs, hepatic or renal impairment: reduce dose. Maintenance of ICU sedation: 0.2–0.7mcg/kg/hr; >65yrs, hepatic or renal impairment: reduce dose. Initiation of procedural sedation: loading infusion of 1mcg/kg over 10 minutes, less invasive procedures: 0.5mcg/kg over 10 minutes. Awake fiberoptic intubation patients: loading infusion of 1mcg/kg over 10 minutes. >65yrs: loading infusion of 0.5mcg/kg over 10 minutes. Hepatic or renal impairment: reduce dose. Maintenance of procedural sedation: initially 0.6mcg/kg/hr and titrated to achieve desired effect with doses ranging from 0.2–1mcg/kg/hr. Awake fiberoptic intubation patients:0.7mcg/kg/hr until endotracheal tube is secured. >65yrs, renal or hepatic impairment: reduce dose.