Pramipexole has some of the same effects as a chemical called dopamine, which occurs naturally in your body. Low levels of dopamine in the brain are associated with Parkinson’s disease.

Pramipexole is used to treat symptoms of Parkinson’s disease (stiffness, tremors, muscle spasms, and poor muscle control). Pramipexole is also used to treat restless legs syndrome (RLS).

Only immediate-release pramipexole (Mirapex) is approved to treat either Parkinson symptoms or RLS. Extended-release pramipexole (Mirapex ER) is approved only to treat Parkinson symptoms.

Parkinson’s and RLS are two separate disorders. Having one of these conditions will not cause you to have the other condition.

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  • Mirapex, Mirapex ER
  • More common
    Dizziness, lightheadedness, or fainting, especially when standing up suddenly from a sitting/lying position
    drowsiness
    hallucinations (seeing, hearing, or feeling things that are not there)
    nausea
    trouble sleeping
    twitching, twisting, or other unusual body movements
    unusual tiredness or weakness
    Less common
    Confusion
    cough
    difficulty with swallowing
    double vision or other changes in vision
    falling asleep without warning
    fearfulness, suspiciousness, or other mental changes
    fever
    frequent urination
    memory loss
    muscle or joint pain
    muscle weakness
    restlessness or need to keep moving
    swelling of the body
    tightness in the chest
    troubled breathing
    writhing, twisting, or other unusual body movements
    Rare
    Abnormal thinking
    anxiety
    bloody or cloudy urine
    chest pain
    difficult, burning, or painful urination
    dizziness
    frequent urge to urinate
    loss of bladder control
    swelling of the arms or legs
    Some pramipexole side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

    More common
    Constipation
    dryness of the mouth
    headache
    heartburn, indigestion, or acid stomach
    Less common
    Abnormal dreams
    decreased sexual drive or ability
    general feeling of discomfort or illness
    increased cough
    increased sweating
    itching
    joint pain
    loss of appetite
    runny nose
    skin problems, such as rash or itching
    weight loss
  • (oral tablet, oral tablet, extended release)