Pramipexole has some of the same effects as a chemical called dopamine, which occurs naturally in your body. Low levels of dopamine in the brain are associated with Parkinson’s disease.
Pramipexole is used to treat symptoms of Parkinson’s disease (stiffness, tremors, muscle spasms, and poor muscle control). Pramipexole is also used to treat restless legs syndrome (RLS).
Only immediate-release pramipexole (Mirapex) is approved to treat either Parkinson symptoms or RLS. Extended-release pramipexole (Mirapex ER) is approved only to treat Parkinson symptoms.
Parkinson’s and RLS are two separate disorders. Having one of these conditions will not cause you to have the other condition.
Mirapex, Mirapex ER
Dizziness, lightheadedness, or fainting, especially when standing up suddenly from a sitting/lying position
hallucinations (seeing, hearing, or feeling things that are not there)
twitching, twisting, or other unusual body movements
unusual tiredness or weakness
difficulty with swallowing
double vision or other changes in vision
falling asleep without warning
fearfulness, suspiciousness, or other mental changes
muscle or joint pain
restlessness or need to keep moving
swelling of the body
tightness in the chest
writhing, twisting, or other unusual body movements
bloody or cloudy urine
difficult, burning, or painful urination
frequent urge to urinate
loss of bladder control
swelling of the arms or legs
Some pramipexole side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:
dryness of the mouth
heartburn, indigestion, or acid stomach
decreased sexual drive or ability
general feeling of discomfort or illness
loss of appetite
skin problems, such as rash or itching
(oral tablet, oral tablet, extended release)