Posaconazole is an antifungal medicine that fights certain infections caused by fungus.

Posaconazole is used to prevent fungal infections in people who have a weak immune system resulting from certain treatments or conditions (such as chemotherapy, stem cell transplantation, HIV infection, and others).

Posaconazole is also used to treat oral thrush (yeast infection of the mouth).

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  • Noxafil
  • More common
    Abdominal or stomach pain
    black, tarry stools
    bloody nose
    blurred vision
    body aches or pain
    confusion
    cough
    diarrhea
    difficult or labored breathing
    dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
    drowsiness
    fever or chills
    fruit-like breath odor
    heavy non-menstrual vaginal bleeding
    increased thirst or urination
    irregular heartbeats
    loss of voice
    muscle pain, spasms, or twitching
    nausea or vomiting
    numbness or tingling in the hands, feet, lips, mouth, or fingertips
    painful cold sores or blisters on the lips, nose, eyes, or genitals
    painful or difficult urination
    pounding in the ears
    slow or fast heartbeat
    small red or purple spots on the skin
    sores, ulcers, or white spots on the lips, tongue, or inside the mouth
    sweating
    tender, swollen glands in the neck
    tightness in the chest
    trembling
    trouble swallowing
    unexplained weight loss
    yellow eyes or skin
    Less common
    Fainting
    irregular heartbeat, recurrent
    Incidence not known
    Anxiety
    change in mental status
    chest pain or discomfort
    darkening of the skin
    itching or skin rash
    mental depression
    seizures
    sudden shortness of breath or troubled breathing
    swelling of the eyes or eyelids
    swelling of the face, fingers, feet, or lower legs
    weakness
    Some posaconazole side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

    More common
    Acid or sour stomach
    back pain
    belching
    difficulty having a bowel movement (stool)
    heartburn
    muscle stiffness
    pain in the joints
    trouble sleeping
    Less common
    Bad, unusual, or unpleasant (after) taste
    change in taste
  • (oral suspension, oral delayed release tablet, intravenous solution)