PLIAGLIS (lidocaine and tetracaine) Cream 7% / 7% is a topical local anesthetic cream that forms a pliable peel on the skin when exposed to air. The drug formulation is an emulsion in which the oil phase is a 1:1 eutectic mixture of lidocaine 7% and tetracaine 7%. The eutectic mixture has a melting point below room temperature and therefore both local anesthetics exist as a liquid oil rather than as crystals.

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  • Pliaglis
  • Flushing or redness of the skin
    swelling
    unusually warm skin
    Less common:
    Blistering, burning, crusting, dryness, or flaking of the skin
    change in the color of treated skin
    itching, scaling, severe redness, soreness, or swelling of the skin
    rash
    Rare:
    Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
    cough or hoarseness
    fainting or loss of consciousness
    fast or irregular breathing
    fever or chills
    hives or welts
    lower back or side pain
    painful or difficult urination
    swelling of the eyes or eyelids
    tightness in the chest or wheezing
    trouble with breathing
  • For superficial dermatological procedures such as dermal filler injection, non-ablative laser facial resurfacing, or pulsed-dye laser therapy, apply PLIAGLIS Cream to intact skin for 20-30 minutes prior to the procedure. See Table 1 for instructions on the amount to apply. • For superficial dermatological procedures such as laser-assisted tattoo removal, apply PLIAGLIS Cream to intact skin for 60 minutes prior to the procedure. See Table 1 for instructions on the amount to apply. The dose of PLIAGLIS Cream that provides effective local dermal analgesia depends on the duration of the application. Although not specifically studied, a shorter duration of application may result in a less complete dermal analgesia or a shorter duration of adequate dermal analgesia.