Pirfenidone is used to treat a lung disease called idiopathic pulmonary fibrosis (IPF). IPF causes scar tissue to form deep within your lungs. The scar tissue thickens and becomes stiff or thick over time, which can make it harder for your lungs to work. Decreased lung function can make it hard for you to breathe. Other medical problems can occur when your brain, heart, and other organs do not get enough oxygen.

The cause of IPF is often unknown, but this condition is a progressive disease that can be fatal. Pirfenidone is not a cure for IPF, but this medicine may slow the progress of this disease.

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  • Esbriet
  • More common
    Diarrhea
    itching or skin rash
    nausea
    redness or other discoloration of the skin
    severe sunburn
    stomach discomfort, upset, or pain
    vomiting
    Incidence not known
    Cough or hoarseness
    fever with or without chills
    general feeling of tiredness or weakness
    large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
    lower back or side pain
    painful or difficult urination
    sore throat
    sores, ulcers, or white spots on the lips or in the mouth
    unusual bleeding or bruising
    Some pirfenidone side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

    More common
    Acid or sour stomach
    body aches or pain
    change in taste
    dizziness
    ear congestion
    headache
    heartburn or indigestion
    increased sensitivity of the skin to sunlight
    joint or muscle pain
    lack or loss of strength
    loss of appetite
    pain or tenderness around the eyes and cheekbones
    sneezing
    stuffy or runny nose
    trouble sleeping
    unusual tiredness or weakness
    weight loss
  • (oral capsule)