Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Promethazine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Phenylephrine and promethazine is a combination medicine used to treat sneezing, runny nose, watery eyes, hives, skin rash, itching, and other cold or allergy symptoms.

Phenylephrine and promethazine may also be used for purposes not listed in this medication guide.

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  • Phenergan VC, Promethazine VC Plain
  • Stop using this medicine and call your doctor at once if you have:

    seizure (convulsions);
    weak or shallow breathing;
    jaundice (yellowing of the skin or eyes);
    confusion, hallucinations;
    sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing;
    uncontrollable movements of your eyes, lips, tongue, face, arms, or legs; or
    severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.
    Common side effects may include:

    dizziness, drowsiness;
    dry mouth, nose, or throat;
    blurred vision; or
    constipation.
  • Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. This medicine is usually taken only for a short time until your symptoms clear up. Do not give this medicine to a child younger than 2 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one. Do not take for longer than 7 days in a row. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache or skin rash. If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken this medicine within the past few days.