Pegaspargase is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Pegaspargase is used in combination with other cancer medications to treat acute lymphoblastic leukemia. This medicine is also used to treat allergic reactions to another cancer medication called asparaginase (Elspar).

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  • Oncaspar
  • More common
    Abdominal or stomach pain
    blurry vision
    constipation
    dry mouth and skin
    faintness
    fatigue
    fruit-like breath odor
    increased hunger or thirst
    increased need to urinate
    nausea
    skin paleness
    skin rash
    sweating
    troubled breathing
    unexplained weight loss
    unusual bleeding or bruising
    vomiting
    Less common
    Bloating
    chest pain
    confusion
    cough
    darkened urine
    difficulty in breathing or swallowing
    dizziness
    fast heartbeat
    fever or chills
    headache
    hives or itching
    indigestion
    itching, especially of hands and feet
    loss of appetite
    numbness, tingling, or swelling in arms or legs
    pains in stomach, side, or abdomen, possibly radiating to the back
    puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
    reddening of the skin, especially around ears
    shortness of breath
    swelling of eyes, face, or inside of nose
    tightness in chest
    unusual tiredness or weakness (sudden and severe)
    wheezing
    yellow eyes or skin
    Rare
    Black, tarry stools
    blood in urine
    hoarseness
    lower back or side pain
    painful or difficult urination
    pinpoint red spots on skin
    Some pegaspargase side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

    More common
    General feeling of discomfort or illness
    Less common
    Anxiety
    behavior change similar to drunkenness
    blurred vision
    cold sweats
    convulsions (seizures)
    cool pale skin
    difficulty in concentrating
    drowsiness
    lack of appetite
    nervousness
    nightmares
    pain at place of injection
    pain in joints or muscles
    restless sleep
    shakiness
    slurred speech
  • (injectable solution)