Pasireotide is a man-made protein that is similar to a hormone in the body called somatostatin. Pasireotide lowers certain hormone substances produced in the body.

Pasireotide is used to treat Cushing’s disease or acromegaly (endocrine disorders). Pasireotide is usually given after surgery or other treatments have been tried without success.

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  • Signifor, Signifor LAR
  • More common
    Abdominal or stomach pain or fullness
    anxiety
    bloating or swelling of the face, arms, hands, lower legs, or feet
    blurred vision
    chills
    cold sweats
    coma
    confusion
    convulsions
    cool, pale skin
    darkening of the skin
    decreased urine
    depression
    diarrhea
    dizziness
    dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
    dry mouth
    fainting
    flushed, dry skin
    fruit-like breath odor
    gaseous abdominal or stomach pain
    headache
    increased hunger
    increased thirst
    increased urination
    irregular heartbeat
    loss of appetite
    loss of consciousness
    muscle pain or cramps
    nausea or vomiting
    nightmares
    numbness or tingling in the hands, feet, or lips
    pounding in the ears
    rapid weight gain
    recurrent fever
    seizures
    shakiness
    skin rash
    slow or fast heartbeat
    slurred speech
    sweating
    tingling of the hands or feet
    troubled breathing
    unexplained weight loss
    unusual tiredness or weakness
    unusual weight gain or loss
    yellow eyes or skin
    Incidence not known
    Clay-colored stools
    constipation
    darkened urine
    dry skin and hair
    feeling cold
    fever
    hair loss
    hoarseness or husky voice
    indigestion
    itching
    loss of appetite
    muscle stiffness
    pains in the stomach, side, or abdomen, possibly radiating to the back
    unpleasant breath odor
    vomiting of blood
    weight gain
    Some pasireotide side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

    More common
    Back pain
    bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
    cough
    decreased appetite
    difficulty with moving
    feeling of constant movement of self or surroundings
    general feeling of discomfort or illness
    joint pain
    lack or loss of strength
    pain in the arms or legs
    pressure in the stomach
    sensation of spinning
    shivering
    stuffy or runny nose
    sweating
    swelling of the abdominal or stomach area
    swollen joints
    trouble sleeping
    upper abdominal or stomach pain
  • (subcutaneous solution, intramuscular powder for injection, extended release)