Paroxetine is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Paroxetine affects chemicals in the brain that may be unbalanced in people with depression, anxiety, or other disorders.

Paroxetine is used to treat depression, obsessive-compulsive disorder, anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD).

The Brisdelle brand of paroxetine is used to treat hot flashes related to menopause. Brisdelle is not for treating any other conditions.

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  • Brisdelle, Paxil, Paxil CR, Pexeva
  • Less common
    Agitation
    chest congestion
    chest pain
    chills
    cold sweats
    confusion
    difficulty with breathing
    dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
    fast, pounding, or irregular heartbeat or pulse
    muscle pain or weakness
    skin rash
    Rare
    Absence of or decrease in body movements
    bigger, dilated, or enlarged pupils (black part of the eye)
    convulsions (seizures)
    difficulty with speaking
    dry mouth
    fever
    inability to move the eyes
    incomplete, sudden, or unusual body or facial movements
    increased sensitivity of the eyes to light
    poor coordination
    red or purple patches on the skin
    restlessness
    shivering
    sweating
    talking, feeling, and acting with excitement and activity you cannot control
    trembling or shaking, or twitching
    Incidence not known
    Back, leg, or stomach pains
    blindness
    blistering, peeling, or loosening of the skin
    blue-yellow color blindness
    blurred vision
    constipation
    cough or hoarseness
    dark urine
    decreased frequency or amount of urine
    decreased vision
    difficulty with swallowing
    electric shock sensations
    eye pain
    fainting
    general body swelling
    headache
    high fever
    hives or itching skin
    inability to move the arms and legs
    inability to sit still
    increased thirst
    incremental or ratchet-like movement of the muscle
    joint pain
    light-colored stools
    lockjaw
    loss of appetite
    loss of bladder control
    lower back or side pain
    muscle spasm, especially of the neck and back
    muscle tension or tightness
    painful or difficult urination
    painful or prolonged erection of the penis
    pale skin
    puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
    raised red swellings on the skin, the buttocks, legs, or ankles
    red, irritated eyes
    sensitivity to the sun
    skin redness or soreness
    slow heart rate
    sores, ulcers, or white spots on the lips or in the mouth
    spasms of the throat
    stiff muscles
    stomach pain
    sudden numbness and weakness in the arms and legs
    swelling of the breasts
    swelling of the face, fingers, or lower legs
    swollen or painful glands
    tightness in the chest
    unexpected or excess milk flow from the breasts
    unusual bleeding or bruising
    unusual tiredness or weakness
    vomiting
    weight gain
    yellowing of the eyes or skin
    Some paroxetine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

    More common
    Acid or sour stomach
    belching
    decreased appetite
    decreased sexual ability or desire
    heartburn
    pain or tenderness around the eyes and cheekbones
    passing gas
    problems with urinating
    runny or stuffy nose
    sexual problems, especially ejaculatory disturbances
    sleepiness or unusual drowsiness
    stomach discomfort or upset
    trouble sleeping
    Less common
    Abnormal dreams
    change in sense of taste
    congestion
    discouragement, feeling sad, or empty
    drugged feeling
    fast or irregular breathing
    feeling of unreality
    headache, severe and throbbing
    increased appetite
    itching of the vagina or genital area
    itching, pain, redness, or swelling of the eye or eyelid
    lack of emotion
    loss of interest or pleasure
    lump in the throat
    menstrual changes
    pain during sexual intercourse
    problems with memory
    sense of detachment from self or body
    sneezing
    thick, white vaginal discharge with no odor or with a mild odor
    tightness in the throat
    tingling, burning, or prickling sensations
    trouble concentrating
    voice changes
    watering of the eyes
    weight loss
    yawn
  • (oral tablet, extended release, oral tablet, oral suspension, oral capsule)