Pamidronate is in a group of medicines called bisphosphonates (bis FOS fo nayts). It alters the cycle of bone formation and breakdown in the body.

Pamidronate is used to treat high levels of calcium in the blood related to cancer (also called hypercalcemia of malignancy). Pamidronate is also used to treat Paget’s disease of bone.

Pamidronate is used to treat bone damage caused by certain types of cancer such as breast cancer or bone marrow cancer. Pamidronate does not treat cancer. Use all other medications your doctor has prescribed for those conditions.

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  • Aredia
  • More common
    Abdominal or stomach cramps
    black, tarry stools
    bloody in the urine or stools
    blurred vision
    chest pain
    chills
    confusion
    convulsions (seizures)
    decrease in the amount of urine
    dizziness
    drowsiness
    fainting
    fast or irregular heartbeat
    fever
    headache
    increased thirst
    loss of appetite
    muscle pain, cramps, spasms, or twitching
    nausea or vomiting
    nervousness
    noisy, rattling breathing
    numbness or tingling in the hands, feet, or lips
    pinpoint red spots on the skin
    pounding in the ears
    shortness of breath
    slow or fast heartbeat
    swelling of the fingers, hands, feet, or lower legs
    trembling
    troubled breathing at rest
    unusual bleeding or bruising
    unusual tiredness or weakness
    vomiting of blood or material that looks like coffee grounds
    weight gain
    Less common
    Cough
    dilated neck veins
    extreme fatigue
    irregular breathing
    lower back or side pain
    painful or difficult urination
    pale skin
    swelling
    ulcers, sores, or white spots in the mouth
    Rare
    Decreased vision
    difficulty with swallowing
    eye pain or tenderness
    eye redness
    hives
    itching
    large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
    sensitivity of the eye to light
    skin rash
    sweating
    tearing of the eye
    tightness in the chest
    Incidence not known
    Bone, joint, or muscle pain, severe and occasionally incapacitating
    faintness, or lightheadedness when getting up suddenly from a lying or sitting position
    Some pamidronate side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

    More common
    Acid or sour stomach
    belching
    bladder pain
    bloody or cloudy urine
    body aches or pain
    bone pain
    constipation
    cracks in the skin at the corners of mouth
    diarrhea
    difficult, burning, or painful urination
    difficult or labored breathing
    difficulty moving
    ear congestion
    fear
    frequent urge to urinate
    heartburn
    indigestion
    joint pain
    lack or loss of strength
    lower back or side pain
    muscle aching, cramping, pains, or stiffness
    nasal congestion
    nervousness
    pain and swelling at the injection site
    sensitivity to heat
    shivering
    sneezing
    soreness or redness around the fingernails and toenails
    stomach discomfort, upset, or pain
    sweating
    swollen joints
    trouble sleeping
    weight loss
    Less common
    Ammonia-like breath odor
    feeling, seeing, or hearing things that are not there
    feeling that others are watching you or controlling your behavior
    feeling that others can hear your thoughts
    feeling unusually cold
    swelling or inflammation of the mouth
    unusual behavior
  • (intravenous solution, intravenous powder for injection)