Opana (oxymorphone) is an opioid pain medication. An opioid is sometimes called a narcotic.

Opana is used to treat moderate to severe pain.

The extended-release form of this medicine is for around-the-clock treatment of severe pain. Opana ER is not for use on an as-needed basis for pain.

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  • Opana, Opana ER
  • Less common
    Blurred vision
    confusion
    decreased urination
    difficult or labored breathing
    dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
    dry mouth
    fast, pounding, racing, or irregular heartbeat or pulse
    headache
    nervousness
    pounding in the ears
    rapid breathing
    sunken eyes
    sweating
    swelling of the hands, ankles, or feet
    thirst
    tightness in the chest
    unusual tiredness or weakness
    wrinkled skin
    Rare
    Abdominal or stomach pain
    chest pain or discomfort
    chills
    cold sweats
    cough
    decrease in consciousness
    decrease in urine volume
    difficulty in passing urine (dribbling)
    difficulty with sleeping
    difficulty with swallowing
    disorientation
    drowsiness to profound coma
    fever
    hallucination
    hives, itching, or skin rash
    hyperventilation
    hoarseness
    irregular, slow, or shallow breathing
    irritability
    irritation
    joint pain, stiffness, or swelling
    lethargy
    painful urination
    pale or blue lips, fingernails, or skin
    puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
    redness of the skin
    restlessness
    severe constipation
    severe vomiting
    shaking
    trouble in holding or releasing urine
    If any of the following symptoms of overdose occur while taking oxymorphone, get emergency help immediately:

    Symptoms of overdose
    Cold and clammy skin
    constricted, pinpoint, or small pupils (black part of the eye)
    decreased awareness or responsiveness
    muscle weakness
    no blood pressure or pulse
    not breathing
    severe sleepiness or unusual drowsiness
    stopping of heart
    Some oxymorphone side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

    More common
    Difficulty having a bowel movement (stool)
    feeling of constant movement of self or surroundings
    increased sweating
    nausea or vomiting
    relaxed and calm
    sensation of spinning
    sleepiness
    Less common
    Acid or sour stomach
    belching
    decreased appetite
    decreased weight
    diarrhea
    discouragement
    excess air or gas in the stomach or intestines
    feeling of warmth
    feeling sad or empty
    full or bloated feeling
    heartburn
    indigestion
    lack of appetite
    loss of interest or pleasure
    passing gas
    pressure in the stomach
    redness of the face, neck, arms, and occasionally, upper chest
    stomach discomfort or upset
    swelling of the abdominal or stomach area
    tiredness
    trouble concentrating
    Rare
    Blistering, crusting, irritation, itching, or reddening of the skin
    cracked, dry, scaly skin
    difficulty with thinking or concentrating
    disturbed color perception
    double vision
    false or unusual sense of well-being
    feeling jittery
    halos around lights
    loss of vision
    mental depression
    night blindness
    nightmares or unusually vivid dreams
    overbright appearance of lights
    sudden sweating
    tunnel vision
    welts
  • (oxymorphone hydrochloride) tablet