Denileukin diftitox is a designed protein containing toxins that attach themselves to certain types of malignant cells in the body. Denileukin diftitox works by destroying these malignant cells to slow the progression of cancer.

Denileukin diftitox is used to treat leukemia and lymphomas, including cutaneous (of the skin) T-cell lymphoma.

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  • Ontak
  • More common
    Back pain
    bloating or swelling of the face, arms, hands, lower legs, or feet
    blurred vision
    body aches or pain
    chest pain
    confusion
    cough
    difficulty with breathing
    difficulty with moving
    difficulty with swallowing
    dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
    ear congestion
    fast or irregular heartbeat
    feeling unusually cold
    fever or chills
    headache
    loss of appetite
    loss of strength or energy
    loss of voice
    muscle aching or cramping
    muscle pains or stiffness
    nasal congestion
    nausea
    pain in the joints and muscles
    rapid weight gain
    rash
    runny nose
    shivering
    shortness of breath
    sneezing
    sore throat
    sweating
    swollen joints
    tightness in the chest
    tingling of the hands or feet
    unusual tiredness or weakness
    unusual weight gain or loss
    vomiting
    warmth and flushing of the skin
    wheezing
    Less common
    Abdominal pain, severe
    black, tarry stools
    blood in the urine or stools
    cloudy urine
    cough or hoarseness accompanied by fever or chills
    headache, severe
    loss of coordination
    lower back or side pain accompanied by fever or chills
    pain in the groin or leg
    painful or difficult urination accompanied by fever or chills
    pinpoint red spots on the skin
    slurring of speech
    sudden vision changes
    swelling or pain at the injection site
    unusual bleeding or bruising
    weakness of the arm and leg
    Rare
    Dry, puffy skin
    increased heart rate
    weight gain
    Some denileukin diftitox side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

    More common
    Change in taste
    diarrhea
    itching
    loss of taste
    Less common
    Constipation
    indigestion
    numbness or tingling of the fingers, toes, or face
    runny nose
    trouble with sleeping
  • (denileukin diftitox) injection, solution