Olanzapine is an antipsychotic medication that affects chemicals in the brain.

Olanzapine is used to treat the symptoms of psychotic conditions such as schizophrenia and bipolar disorder (manic depression) in adults and children who are at least 13 years old.

Olanzapine is sometimes used together with other antipsychotic medications or antidepressants.

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  • ZyPREXA, ZyPREXA Zydis
  • More common
    Bloating or swelling of the face, arms, hands, lower legs, or feet
    blurred vision
    change in vision
    change in walking and balance
    clumsiness or unsteadiness
    difficulty with speaking
    difficulty with swallowing
    drooling
    impaired vision
    inability to sit still
    loss of balance control
    mask-like face
    muscle trembling, jerking, or stiffness
    need to keep moving
    rapid weight gain
    restlessness
    shuffling walk
    slowed movements
    slurred speech
    stiffness of the arms and legs
    tic-like (jerky) movements of the head, face, mouth, and neck
    tingling of the hands or feet
    trembling or shaking of the fingers, hands, feet, legs, or arms
    twisting movements of the body
    uncontrolled movements, especially of the face, neck, and back
    unusual weight gain or loss
    Less common
    Bladder pain
    bloody or cloudy urine
    bruising
    burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
    chest pain
    difficult or labored breathing
    difficult, burning, or painful urination
    dizziness
    excessive muscle tone
    frequent urge to urinate
    headache
    inability to move the eyes
    increased blinking or spasms of the eyelid
    itching of the vagina or genital area
    lack of coordination
    large, flat, blue, or purplish patches in the skin
    loss of bladder control
    loss of memory
    lower back or side pain
    muscle tension or tightness
    nervousness
    pain during sexual intercourse
    pounding in the ears
    problems with memory
    rhythmic movement of the muscles
    shortness of breath
    slow, fast, pounding, or irregular heartbeat or pulse
    speaking is less clear than usual
    sticking out the tongue
    thick, white vaginal discharge with no odor or with a mild odor
    tightness in the chest
    twitching
    uncontrolled twisting movements of the neck, trunk, arms, or legs
    unusual or incomplete body or facial movements
    weakness of the arms and legs
    Some olanzapine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

    More common
    Acid or sour stomach
    back pain
    belching
    change in personality
    difficulty having a bowel movement (stool)
    discouragement
    feeling sad or empty
    fever
    heartburn
    increased appetite
    increased cough
    indigestion
    lack of appetite
    lack or loss of strength
    loss of interest or pleasure
    runny nose
    sleeplessness
    sneezing
    stomach discomfort, upset, or pain
    stuffy nose
    thirst
    trouble with concentrating
    unable to sleep
    watering of the mouth
    Less common
    Blemishes on the skin
    body aches or pain
    chills
    cold sweats
    congestion
    cough
    dry skin
    dryness or soreness of the throat
    false or unusual sense of well-being
    heavy menstrual bleeding (periods)
    hoarseness
    joint pain
    lack of feeling or emotion
    leg cramps
    pain in the arms or legs
    pimples
    sweating
    tender, swollen glands in the neck
    uncaring feelings
    voice change
    vomiting
  • (oral tablet, oral tablet, disintegrating, intramuscular powder for injection, intramuscular powder for injection, extended release)