Desipramine is a tricyclic antidepressant. Desipramine affects chemicals in the brain that may become unbalanced.

Desipramine is used to treat symptoms of depression.

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  • Norpramin
  • Incidence not known
    Abdominal or stomach pain
    anxiety
    black, tarry stools
    blurred or double vision
    burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
    chest pain or discomfort
    confusion about identity, place, and time
    convulsions
    cough or hoarseness
    dark urine
    dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
    dry mouth
    fainting
    fast, irregular, pounding, or racing heartbeat or pulse
    inability to move the arms, legs, or facial muscles
    inability to speak
    irritability
    light-colored stools
    lightheadedness
    loss of appetite
    loss of bladder control
    muscle spasms or jerking of all extremities
    nausea
    nightmares
    pain or discomfort in the arms, jaw, back, or neck
    painful or difficult urination
    pinpoint red or purple spots on the skin
    pounding in the ears
    rash
    restlessness
    seeing, hearing, or feeling things that are not there
    shakiness and unsteady walk
    slow speech
    sore throat and fever
    sores, ulcers, or white spots on the lips or in the mouth
    stiffness of the limbs
    sudden loss of consciousness
    sweating
    swelling
    swollen glands
    talking, feeling, and acting with excitement
    trouble sleeping
    twisting body movements
    unsteadiness, trembling, or problems with muscle control or coordination
    unusual bleeding or bruising
    unusual tiredness or weakness
    vomiting
    yellow eyes and skin
    Some desipramine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

    Incidence not known
    Abdominal or stomach cramps
    bigger, dilated, or enlarged pupils (black part of the eye)
    bloating
    constipation
    decrease in the frequency of urination
    decrease in urine volume
    decreased interest in sexual intercourse
    diarrhea
    difficulty in passing urine (dribbling)
    hair loss or thinning of the hair
    inability to have or keep an erection
    increased in sexual ability, desire, drive, or performance
    increased interest in sexual intercourse
    increased sensitivity of the eyes to light
    loss in sexual ability, desire, drive, or performance
    painful urination
    swelling of the breasts or breast soreness in both females and males
    swelling or inflammation of the mouth
    unexpected or excess milk flow from breasts in females
  • (desipramine hydrochloride) tablet, sugar coated