Treating moderate to severe Pneumocystis carinii pneumonia (PCP) in patients with weak immune systems, including those with AIDS, who are not able to take the standard treatment. Neutrexin is used in combination with leucovorin.

Neutrexin is an anti-infective agent. It works by inhibiting DNA, RNA, and protein synthesis, leading to cell death.

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  • Neutrexin
  • More common
    Abdominal pain or tenderness
    black, tarry stools
    blood in urine or stools
    clay-colored stools
    dark urine
    decreased appetite
    fever and sore throat
    headache
    itching
    loss of appetite
    nausea and vomiting
    pinpoint red spots on skin
    skin rash
    swelling of feet or lower legs
    unusual bleeding or bruising
    unusual tiredness or weakness
    yellow eyes or skin
    Less common
    Abdominal cramps
    coma
    confusion
    convulsions
    decreased urine output
    difficulty in breathing
    dizziness
    fast or irregular heartbeat
    hypocalcemia
    increased thirst
    mood or mental changes
    muscle cramps in hands, arms, feet, legs, or face
    muscle pain
    mouth sores or ulcers
    numbness and tingling around the mouth, fingertips, or feet
    skin rash and itching
    shortness of breath
    tremor
    Rare
    Cough
    difficulty swallowing
    fainting or loss of consciousness
    fast or irregular breathing
    hives
    puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
    swelling of eyes or eyelids
    tightness in chest
    trouble in breathing
    wheezing
    Some trimetrexate side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

    Less common
    Fatigue
    stomach pain
  • (trimetrexate glucuronate) for Injection