Natalizumab is a monoclonal antibody that affects the actions of the body’s immune system. Monoclonal antibodies are made to target and destroy only certain cells in the body. This may help to protect healthy cells from damage.

Natalizumab is used to treat relapsing forms of multiple sclerosis.

Natalizumab is also used to treat moderate to severe Crohn’s disease in adults. It is usually given after other Crohn’s disease medications have been tried without successful treatment of this condition.

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  • Tysabri
  • More common
    Body produces substance that can bind to drug making it less effective or cause side effects
    cough
    difficulty with swallowing
    dizziness
    fast heartbeat
    puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
    shortness of breath
    skin rash, hives, or itching
    tightness in the chest
    unusual tiredness or weakness
    Rare
    Abdominal or stomach fullness
    blurred vision
    changes in behavior
    chest pain
    confusion
    difficult or labored breathing
    faintness or lightheadedness when getting up suddenly from a lying or sitting position
    feeling of warmth
    feeling unusually cold
    fever
    gaseous abdominal or stomach pain
    nausea
    redness of the face, neck, arms, and occasionally, upper chest
    shivering
    sneezing
    sore throat
    sweating
    thoughts of killing oneself
    yellow eyes or skin
    Incidence not known
    Back pain
    convulsions
    drowsiness
    headache
    Some natalizumab side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

    More common
    Bladder pain
    blistering, crusting, irritation, itching, or reddening of the skin
    bloody or cloudy urine
    cracked, dry, scaly skin
    diarrhea
    difficult, burning, or painful urination
    difficulty with moving
    discouragement
    feeling sad or empty
    frequent, strong, or increased urge to urinate
    irregular menstruation
    irritability
    itching of the vagina or genital area
    loss of appetite
    loss of interest or pleasure
    lower back or side pain
    muscle pain or stiffness
    pain during sexual intercourse
    pain in the joints
    pain, cramps, or heavy bleeding
    passing urine more often
    stomach pain
    stomach soreness or discomfort
    swelling
    swollen glands
    thick, white vaginal discharge with no odor or with a mild odor
    trouble concentrating
    trouble sleeping
    Less common
    Absent, missed, or irregular menstrual periods
    chest discomfort
    fainting
    local bleeding
    shakiness in the legs, arms, hands, or feet
    stopping of menstrual bleeding
    trembling or shaking of the hands or feet
  • (intravenous concentrate)