Naglazyme (galsulfase) is used to treat some of the symptoms of a genetic condition called mucopolysaccharidosis VI (MYOO-koe-pol-ee-SAK-a-rye-DOE-sis type 6), or MPS VI, also called Maroteaux-Lamy syndrome.

MPS VI is a metabolic disorder in which the body lacks the enzyme needed to break down certain sugars and proteins. These substances can build up in the body, causing enlarged organs, abnormal bone structure, changes in facial features, breathing problems, heart problems, vision or hearing loss, and changes in mental or physical abilities.

Naglazyme may improve walking and stair-climbing ability in people with this condition. However, this medication is not a cure for MPS VI.

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  • Naglazyme
  • Less common
    Blurred or decreased vision
    chest pain
    difficult or labored breathing
    dizziness
    headache
    hernia of the naval
    nervousness
    pounding in the ears
    slow or fast heartbeat
    swelling of the face
    tightness in the chest
    Incidence not known
    Back pain
    bluish lips or skin
    confusion
    cough
    dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
    fever, chills, or sweating
    hives or welts
    joint pain
    large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
    loss of bladder control
    loss of bowel control
    nausea or vomiting
    paralysis of the limbs
    stomach pain
    Some galsulfase side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

    More common
    Diarrhea
    ear pain
    loss of appetite
    Less common
    Body aches or pain
    burning, dry, or itching eyes
    congestion
    dryness or soreness of the throat
    excessive tearing
    loss of or increase in reflexes
    runny or stuffy nose
    tender, swollen glands in the neck
    trouble with swallowing
    unusual tiredness or weakness
    voice changes
    Incidence not known
    Difficulty with moving
    loss of voice
    muscle pain or stiffness
    Sneezing
  • (galsulfase) intravenous infusion