Diphenhydramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Antihistamines can cause drowsiness, which can aid in the treatment of occasional sleep problems (insomnia).

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen works by reducing hormones that cause inflammation and pain in the body.

Diphenhydramine and ibuprofen is a combination medicine used to treat occasional insomnia associated with minor aches and pains.

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  • Advil PM, Advil PM Liqui-Gels, Ibuprofen PM, Motrin PM
  • Stop using this medicine and call your doctor at once if you have:

    the first sign of any skin rash, no matter how mild;
    a light-headed feeling, like you might pass out;
    signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
    liver problems--nausea, upper stomach pain, itching, tired feeling, flu-like symptoms, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
    kidney problems--little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath; or
    severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
    Common side effects may include:

    drowsiness;
    day-time drowsiness, dizziness, "hangover" feeling;
    upset stomach, mild heartburn, diarrhea, constipation;
    dry mouth, nose, or throat;
    blurred vision;
    mild itching or rash; or
    ringing in your ears.
  • do not take more than directed do not take longer than 10 days, unless directed by a doctor (see Warnings) adults and children 12 years and over: take 2 caplets at bedtime do not take more than 2 caplets in 24 hours