Milnacipran affects certain chemicals in the brain called neurotransmitters. An abnormality in these chemicals is thought to be related to fibromyalgia (a medical condition that causes chronic pain in the muscles and joints). Milnacipran is not used to treat depression but it works similarly to how some antidepressants work.

Milnacipran is used to treat the chronic pain caused by fibromyalgia.

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  • Savella
  • More common
    Blurred vision
    body aches or pain
    chills
    cough
    difficulty with breathing
    dizziness
    ear congestion
    fast, irregular, pounding, or racing heartbeat or pulse
    fear or nervousness
    fever
    headache
    increased sweating
    loss of voice
    nasal congestion
    pounding in the ears
    runny nose
    slow or fast heartbeat
    sneezing
    sore throat
    unusual tiredness or weakness
    Less common
    Back pain
    burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
    chest pain or discomfort
    chills
    decrease in frequency of urination
    decrease in urine volume
    difficult or painful urination
    difficulty in passing urine (dribbling)
    frequent urination
    groin pain
    muscle aches
    pain or burning with urination
    shakiness in the legs, arms, hands, or feet
    swollen, tender prostate
    tightness in the chest
    Rare
    Bladder pain
    bloating or swelling of the face, arms, hands, lower legs, or feet
    bloody or cloudy urine
    bruise
    discouragement
    fall
    feeling sad or empty
    frequent urge to urinate
    full or bloated feeling
    heartburn
    increased or decreased weight
    irritability
    lack of appetite
    loss of interest or pleasure
    lower back or side pain
    pressure in the stomach
    rapid weight gain
    swelling of the abdominal or stomach area
    tingling of the hands or feet
    tiredness
    trouble concentrating
    trouble sleeping
    unusual weight gain or loss
    vomiting
    Incidence not known
    Agitation
    black, tarry stools
    bleeding gums
    blistering, peeling, or loosening of the skin
    blood in the urine or stools
    coma
    confusion as to time, place, or person
    convulsions
    dark-colored urine
    decreased urine output
    diarrhea
    difficulty with swallowing
    general tiredness and weakness
    high fever
    holding false beliefs that cannot be changed by fact
    increased sweating
    increased thirst
    itching
    joint or muscle pain
    light-colored stools
    loss of balance control
    loss of consciousness
    mask-like face
    muscle cramps or spasms
    muscle pain or stiffness
    overactive reflexes
    pinpoint red spots on the skin
    poor coordination
    red skin lesions, often with a purple center
    red, irritated eyes
    restlessness
    seeing, hearing, or feeling things that are not there
    seizures
    severe muscle stiffness
    shuffling walk
    slowed movements
    slurred speech
    sores, ulcers, or white spots on the lips or in the mouth
    stiffness of the arms and legs
    sweating
    swelling of the face, ankles, fingers, or lower legs
    swollen glands
    talking or acting with excitement you cannot control
    tic-like (jerky) movements of the head, face, mouth, and neck
    tiredness
    trembling and shaking of the fingers and hands
    twitching
    unusual bleeding or bruising
    unusual excitement, nervousness, or restlessness
    unusually pale skin
    upper right abdominal or stomach pain
    weight gain
    yellow eyes and skin
    Some of the side effects that can occur with milnacipran may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    More common
    Feeling of warmth
    headache, severe and throbbing
    redness of the face, neck, arms, and occasionally, upper chest
    sudden sweating
    Less common
    Abdominal or stomach pain
    change or problem with discharge of semen
    decreased appetite
    decreased interest in sexual intercourse
    inability to have or keep an erection
    loss in sexual ability, desire, drive, or performance
    not able to ejaculate semen
    rash
    swelling of the testes
    Rare
    Acid or sour stomach
    belching
    bloated
    change in taste
    excess air or gas in the stomach or intestines
    full feeling
    heartburn
    indigestion
    irritability
    loss of taste
    night sweats
    passing gas
    sleepiness or unusual drowsiness
    stomach discomfort, upset, or pain
    Incidence not known
    Swelling of the breasts or unusual milk production
    unexpected or excess milk flow from the breasts
  • (oral tablet)