Miglustat reduces the formation of a certain protein in the body in people with type 1 Gaucher disease.

Gaucher disease is a genetic condition in which the body lacks the enzyme needed to break down certain fatty materials (lipids). Lipids can build up in the body, causing symptoms such as easy bruising or bleeding, weakness, anemia, bone or joint pain, enlarged liver or spleen, or weakened bones that are easily fractured.

Miglustat is used to treat mild to moderate type 1 Gaucher disease by people who cannot receive enzyme replacement therapy.

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  • Zavesca
  • More common
    Black, tarry stools
    bleeding gums
    blood in the urine or stools
    burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
    diarrhea
    pinpoint red spots on the skin
    trembling or shaking in the hands
    unsteadiness or awkwardness
    unusual bleeding or bruising
    weakness in the arms, hands, legs, or feet
    weight loss
    Some of the side effects that can occur with miglustat may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    More common
    Back pain
    bloated or full feeling
    blurred or loss of vision
    difficulty having a bowel movement (stool)
    disturbed color perception
    dizziness
    double vision
    dry mouth
    excess air or gas in the stomach or intestines
    halos around lights
    headache
    heartburn
    heaviness in the limbs
    indigestion
    leg cramps
    loss of appetite
    memory loss
    menstrual changes
    nausea
    pain or discomfort in the chest, upper stomach, or throat
    passing gas
    stomach discomfort, upset or pain
    swelling of the abdominal or stomach area
    tunnel vision
    unsteady walk
    vomiting
  • (oral capsule)