Metolazone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Metolazone treats fluid retention (edema) in people with congestive heart failure, or a kidney disorder such as nephrotic syndrome. This medication is also used to treat high blood pressure (hypertension).

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  • Zaroxolyn, Mykrox
  • Incidence not known
    Black, tarry stools
    bleeding gums
    blistering, peeling, or loosening of skin
    bloating
    blood in urine or stools
    blurred vision
    bone pain
    chest pain
    chills
    clay-colored stools
    cold sweats
    coma
    confusion
    constipation
    convulsions
    cough
    dark urine
    decreased urine
    diarrhea
    dizziness, faintness, or lightheadedness when getting up from lying or sitting position
    drowsiness
    dry mouth
    fast, irregular, pounding, or racing heartbeat or pulse
    fever
    flushed, dry skin
    fruit-like breath odor
    general tiredness and weakness
    headache
    incoherent speech
    increased hunger
    increased thirst
    increased urination
    indigestion
    irritability
    itching
    joint or muscle pain
    light-colored stools
    loss of appetite
    lower back or side pain
    metallic taste
    mood changes
    muscle pain or cramps
    nausea and vomiting
    numbness or tingling in hands, feet, or lips
    pain in lower legs
    painful or difficult urination
    pinpoint red spots on skin
    rash
    red irritated eyes
    red skin lesions, often with a purple center
    redness or swelling of lower leg
    shortness of breath
    sore throat
    sores, ulcers, or white spots in mouth or on lips
    sugar in the urine
    sweating
    swelling of face, ankles, or hands
    swollen or painful glands
    tightness in chest
    trembling
    troubled breathing
    unexplained weight loss
    unpleasant breath odor
    unusual bleeding or bruising
    unusual tiredness or weakness
    upper right abdominal pain
    vomiting of blood
    weak pulse
    wheezing
    yellow eyes and skin
    If any of the following symptoms of overdose occur while taking metolazone, get emergency help immediately:

    Symptoms of overdose
    Fainting
    irregular, fast or slow, or shallow breathing
    pale or blue lips, fingernails, or skin
    unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
    weakness and heaviness of legs
    Some of the side effects that can occur with metolazone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    Incidence not known
    Blue-green to black skin discoloration
    burning, tingling, numbness, or pain in the hands, arms, feet, or legs
    cracked, dry, or scaly skin
    decreased interest in sexual intercourse
    feeling of constant movement of self or surroundings
    hives or welts
    inability to have or keep an erection
    loss in sexual ability, desire, drive, or performance
    pain, redness, or sloughing of skin at place of injection
    restlessness
    sensation of pins and needles
    sensation of spinning
    stabbing pain
  • (oral tablet)