Methotrexate interferes with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells.

Methotrexate is used to treat certain types of cancer of the breast, skin, head and neck, or lung. It is also used to treat severe psoriasis and rheumatoid arthritis.

Methotrexate is usually given after other medications have been tried without successful treatment of symptoms.

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  • Rheumatrex Dose Pack, Trexall
  • More common
    Black, tarry stools
    blood in the urine or stools
    bloody vomit
    joint pain
    reddening of the skin
    sores in the mouth or lips
    stomach pain
    swelling of the feet or lower legs
    Less common
    Back pain
    blurred vision
    convulsions (seizures)
    cough or hoarseness
    dark urine
    fever or chills
    lower back or side pain
    painful or difficult urination
    pinpoint red spots on the skin
    shortness of breath
    unusual bleeding or bruising
    unusual tiredness or weakness
    yellow eyes or skin
    Some of the side effects that can occur with methotrexate may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    More common
    Hair loss, temporary
    loss of appetite
    nausea or vomiting
    Less common
    boils on skin
    pale skin
    skin rash or itching
  • (oral tablet, injectable solution, injectable powder for injection, compounding powder, subcutaneous solution)