Mesna is a detoxifying agent. It reduces the harmful effects of the cancer medicine ifosfamide (Ifex).

Mesna is used to prevent bleeding in the bladder (hemorrhagic cystitis) during chemotherapy with ifosfamide (Ifex).

Mesna will not prevent other side effects caused by ifosfamide.

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  • Mesnex
  • More common
    Black, tarry stools
    bleeding gums
    bloating or swelling of the face, arms, hands, lower legs, or feet
    blood in the urine
    chest pain
    chills
    convulsions
    cough
    decreased urination
    dizziness
    dry mouth
    fainting
    fast, pounding, or irregular heartbeat or pulse
    fever
    increased thirst
    irregular heartbeat
    lightheadedness
    loss of appetite
    mood changes
    muscle pain or cramps
    nausea or vomiting
    numbness or tingling in the hands, feet, or lips
    painful or difficult urination
    pinpoint red spots on the skin
    rapid breathing
    rapid weight gain
    sore throat
    sores, ulcers, or white spots on the lips or in the mouth
    sunken eyes
    swelling
    swollen glands
    tightness in the chest
    trouble breathing
    unusual bleeding or bruising
    unusual tiredness or weakness
    unusual weight gain or loss
    wrinkled skin
    Less common
    Blurred vision
    confusion
    dizziness dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
    rapid breathing
    sweating
    Incidence not known
    Coughing or spitting up blood
    dark urine
    general tiredness and weakness
    headache
    light-colored stools
    nervousness
    pounding in the ears
    slow or fast heartbeat
    upper right abdominal or stomach pain
    yellow eyes and skin
    Some of the side effects that can occur with mesna may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    More common
    Abdominal or stomach pain
    diarrhea
    difficulty having a bowel movement (stool)
    hair loss
    lack or loss of strength
    sleepiness or unusual drowsiness
    weight loss
    Less common
    Acid or sour stomach
    back pain
    belching
    feeling of warmth
    heartburn
    increased sweating
    indigestion
    redness of the face, neck, arms, and occasionally, upper chest
    stomach discomfort or upset
    trouble sleeping
    Incidence not known
    Change or loss of taste
  • (intravenous kit, injectable solution, oral tablet)