Mefenamic acid is a nonsteroidal anti-inflammatory drug (NSAID). Mefenamic acid works by reducing hormones that cause inflammation and pain in the body.

Mefenamic acid is used short-term (7 days or less) to treat mild to moderate pain in adults and children who are at least 14 years old. Mefenamic acid is also used to treat menstrual pain.

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  • Ponstel
  • More common
    Bloody urine
    bloody, black, or tarry stools
    decreased frequency or amount of urine
    heartburn
    increased bleeding time
    increased blood pressure
    increased thirst
    indigestion
    itching skin
    loss of appetite
    lower back or side pain
    nausea
    pale skin
    rashes
    severe abdominal pain, cramping, or burning
    stomach bloating
    swelling
    swelling of the face, fingers, feet, or lower legs
    trouble breathing with or without exertion
    unusual bleeding or bruising
    unusual tiredness or weakness
    vomiting
    vomiting of material that looks like coffee grounds, severe and continuing
    weight gain
    weight loss
    Less common
    Bleeding gums
    blood in vomit
    blurred vision
    burning feeling in the chest or stomach
    chest pain
    clay-colored stools
    cloudy urine
    confusion
    constipation
    cough or hoarseness
    dark urine
    difficult or labored breathing
    difficult, burning, or painful urination
    difficulty in swallowing
    dilated neck veins
    dizziness
    extreme fatigue
    fainting
    fast, pounding, or irregular heartbeat or pulse
    fever or chills
    frequent urge to urinate
    headache
    increased volume of pale, dilute urine
    irregular breathing
    irregular heartbeat
    large, flat, blue, or purplish patches in the skin
    light-colored stools
    lightheadedness
    nervousness
    noisy breathing
    pain or burning throat
    pinpoint red or purple spots on the skin
    pounding in the ears
    rapid, slow breathing
    redness, swelling, or soreness of tongue
    severe or continuing stomach pain
    shortness of breath
    slow heartbeat
    sore throat
    sores, ulcers, or white spots on the lips or tongue or inside the mouth
    stomach upset
    swelling or inflammation of the mouth
    swollen glands
    tenderness in the stomach area
    tightness in the chest
    tremors
    unpleasant breath odor
    upper right abdominal pain
    weight changes
    wheezing
    yellow eyes and skin
    Rare
    Blistering, peeling, or loosening of the skin
    change in consciousness
    chest discomfort
    continuing vomiting
    cracks in the skin
    diarrhea
    dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
    drowsiness
    fever with or without chills
    flushed, dry skin
    fruit-like breath odor
    general body swelling
    general feeling of illness
    high fever
    hives
    increased hunger
    irregular, fast or slow, or shallow breathing
    joint or muscle pain
    large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
    leg pain
    loss of consciousness
    loss of heat from the body
    no blood pressure
    no breathing
    no pulse
    nosebleeds
    painful glands
    pain or discomfort in the arms, jaw, back, or neck
    pains in the stomach, side, or abdomen, possibly radiating to the back
    pale or blue lips, fingernails, or skin
    puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
    racing heartbeat or pulse
    red skin lesions, often with a purple center
    red, irritated eyes
    red, swollen skin
    redness or soreness of the skin
    scaly skin
    seeing, hearing, or feeling things that are not there
    seizures
    severe headache
    sneezing
    sores, welting, or blisters
    stiff neck and/or back
    sweating
    swollen, painful, or tender lymph glands in the neck, armpit, or groin
    unexplained weight loss
    If any of the following symptoms of overdose occur while taking mefenamic acid, get emergency help immediately:

    Symptoms of overdose
    Unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
    Some of the side effects that can occur with mefenamic acid may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    More common
    Acid or sour stomach
    belching
    continuing ringing or buzzing or other unexplained noise in the ears
    excess air or gas in the stomach or intestines
    full feeling
    hearing loss
    passing gas
    stomach discomfort
    Less common
    Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
    discouragement
    dry mouth
    fear
    feeling of constant movement of self or surroundings
    feeling sad or empty
    hair loss, thinning of the hair
    increased sensitivity of skin to sunlight
    irritability
    lack of appetite
    lack of interest or pleasure
    lack or loss of strength
    redness or other discoloration of the skin
    sensation of spinning
    severe sunburn
    sleepiness
    sleeplessness
    trouble concentrating
    trouble sleeping
    unable to sleep
    Rare
    Appetite changes
    burning, dry, or itching eyes
    change in hearing
    discharge, excessive tearing
    redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid
  • (oral capsule)