Medroxyprogesterone is a progestin (a form of progesterone), a female hormone that helps regulate ovulation (the release of an egg from an ovary) and menstrual periods.

Medroxyprogesterone is used to treat conditions such as absent or irregular menstrual periods, or abnormal uterine bleeding. Medroxyprogesterone is also used to decrease the risk of endometrial hyperplasia (a condition that may lead to uterine cancer) while taking estrogens.

Medroxyprogesterone is also used to prevent overgrowth in the lining of the uterus in postmenopausal women who are receiving estrogen hormone replacement therapy.

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  • Provera
  • Incidence not known
    Abdominal or stomach pain
    absent, missed, or irregular menstrual periods
    anxiety
    blurred vision
    breast pain or tenderness
    changes in skin color
    chills
    clay-colored stools
    cough
    dark urine
    decrease in amount of urine
    diarrhea
    difficulty swallowing
    dizziness or lightheadedness
    eye pain
    fainting
    fast heartbeat
    fever
    headache
    hives or welts, itching, redness, swelling, or skin rash
    large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
    loss of appetite
    menstrual changes
    nausea
    noisy, rattling breathing
    pain in the chest, groin, or legs, especially the calves
    pain, tenderness, or swelling of the foot or leg
    puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
    severe, sudden headache
    shortness of breath
    slurred speech
    stopping of menstrual bleeding
    sudden loss of coordination
    sudden, severe weakness or numbness in the arm or leg
    sudden, unexplained shortness of breath
    swelling of the fingers, hands, feet, or lower legs
    troubled breathing at rest
    unexpected or excess milk flow from the breasts
    unpleasant breath odor
    unusual tiredness or weakness
    vaginal bleeding or spotting
    vision changes
    vomiting of blood
    weight gain
    yellow eyes or skin
    Some of the side effects that can occur with medroxyprogesterone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    Incidence not known
    Blemishes on the skin
    discouragement
    feeling sad or empty
    hair loss, thinning of hair
    increased hair growth, especially on the face
    irritability
    lack of appetite
    loss of interest or pleasure
    nervousness
    pimples
    sleepiness or unusual drowsiness
    tiredness
    trouble concentrating
    trouble sleeping
    weight changes
  • (oral tablet, intramuscular suspension, subcutaneous suspension, compounding powder)