Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Triamterene is a potassium-sparing diuretic that also prevents your body from absorbing too much salt and keeps your potassium levels from getting too low.

The combination of hydrochlorothiazide and triamterene is used to treat fluid retention (edema) and high blood pressure (hypertension).

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  • Dyazide, Maxzide, Maxzide-25
  • Stop using hydrochlorothiazide and triamterene and call your doctor at once if you have a serious side effect such as:

    eye pain, vision problems;
    slow, fast, or uneven heartbeat;
    feeling like you might pass out;
    swelling or rapid weight gain;
    urinating less than usual or not at all;
    headache, trouble concentrating, memory problems, weakness, loss of appetite, feeling unsteady, hallucinations, fainting, seizure, shallow breathing or breathing that stops;
    low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling);
    high potassium (irregular heart rate, weak pulse, muscle weakness, tingly feeling);
    severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;
    easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
    patchy skin color, red spots, or a butterfly-shaped skin rash over your cheeks and nose (worsens in sunlight);
    fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
    jaundice (yellowing of the skin or eyes).
    Less serious side effects may include:

    mild nausea, diarrhea, constipation;
    dizziness, headache;
    blurred vision;
    dry mouth;
    skin rash.
  • Your doctor may occasionally change your dose to make sure you get the best results. You will need regular medical tests to be sure this medication is not causing harmful effects. Visit your doctor regularly. If you need surgery or medical tests, tell the doctor ahead of time that you are taking medication that contains hydrochlorothiazide. You may need to stop using the medicine for a short time. Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.